Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.
Probiotics Antimicrob Proteins. 2018 Sep;10(3):496-503. doi: 10.1007/s12602-017-9313-7.
Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidative actions. This study was designed to evaluate the effects of synbiotic administration on biomarkers of inflammation, oxidative stress, and pregnancy outcomes among gestational diabetic (GDM) women. This randomized, double-blind, placebo-controlled clinical trial was carried out among 60 subjects with GDM who were not on oral hypoglycemic agents. Patients were randomly assigned to consume either one synbiotic capsule containing Lactobacillus acidophilus strain T16 (IBRC-M10785), L. casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 10 CFU/g each) plus 800 mg inulin (HPX) (n = 30) or placebo (n = 30) for 6 weeks. Compared with the placebo, synbiotic supplementation significantly decreased serum high-sensitivity C-reactive protein (hs-CRP) (- 1.9 ± 4.2 vs. +1.1 ± 3.5 mg/L, P = 0.004), plasma malondialdehyde (MDA) (- 0.1 ± 0.6 vs. + 0.3 ± 0.7 μmol/L, P = 0.02), and significantly increased total antioxidant capacity (TAC) (+ 70.1 ± 130.9 vs. - 19.7 ± 124.6 mmol/L, P = 0.009) and total glutathione (GSH) levels (+ 28.7 ± 61.5 vs. - 14.9 ± 85.3 μmol/L, P = 0.02). Supplementation with synbiotic had a significant decrease in cesarean section rate (16.7 vs. 40.0%, P = 0.04), lower incidence of hyperbilirubinemic newborns (3.3 vs. 30.0%, P = 0.006), and newborns' hospitalization (3.3 vs. 30.0%, P = 0.006) compared with the placebo. Synbiotic supplementation did not affect plasma nitric oxide (NO) levels and other pregnancy outcomes. Overall, synbiotic supplementation among GDM women for 6 weeks had beneficial effects on serum hs-CRP, plasma TAC, GSH, and MDA; cesarean section; incidence of newborn's hyperbilirubinemia; and newborns' hospitalization but did not affect plasma NO levels and other pregnancy outcomes. http://www.irct.ir : www.irct.ir : IRCT201704205623N108.
共生元被认为具有多种有益作用，包括抗炎和抗氧化作用。本研究旨在评估共生元给药对妊娠期糖尿病（GDM）女性炎症、氧化应激生物标志物和妊娠结局的影响。这是一项随机、双盲、安慰剂对照的临床试验，在 60 名未服用口服降糖药的 GDM 患者中进行。患者被随机分配服用含有嗜酸乳杆菌 T16（IBRC-M10785）、干酪乳杆菌 T2（IBRC-M10783）和双歧杆菌 T1（IBRC-M10771）的共生元胶囊（2×10 CFU/g 各）和 800mg 菊粉（HPX）（n=30）或安慰剂（n=30），共 6 周。与安慰剂相比，共生元补充剂显著降低了血清高敏 C 反应蛋白（hs-CRP）（-1.9±4.2 与+1.1±3.5mg/L，P=0.004）、血浆丙二醛（MDA）（-0.1±0.6 与+0.3±0.7μmol/L，P=0.02），显著增加了总抗氧化能力（TAC）（+70.1±130.9 与-19.7±124.6mmol/L，P=0.009）和总谷胱甘肽（GSH）水平（+28.7±61.5 与-14.9±85.3μmol/L，P=0.02）。共生元补充剂可降低剖宫产率（16.7 与 40.0%，P=0.04）、新生儿高胆红素血症的发生率（3.3 与 30.0%，P=0.006）和新生儿住院率（3.3 与 30.0%，P=0.006）。与安慰剂相比，共生元补充剂对血浆一氧化氮（NO）水平和其他妊娠结局没有影响。总的来说，GDM 女性补充共生元 6 周对血清 hs-CRP、血浆 TAC、GSH 和 MDA、剖宫产、新生儿高胆红素血症发生率和新生儿住院率有有益影响，但对血浆 NO 水平和其他妊娠结局没有影响。http://www.irct.ir : www.irct.ir : IRCT201704205623N108.
