Ashrafi Mohammed, Baguneid Mohamed, Alonso-Rasgado Teresa, Rautemaa-Richardson Riina, Bayat Ardeshir
Plastic & Reconstructive Surgery Research, Centre for Dermatological Research, University of Manchester, Manchester, UK.
University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Future Microbiol. 2017 Mar;12:337-357. doi: 10.2217/fmb-2016-0204. Epub 2017 Mar 3.
Infection contributes significantly to delayed cutaneous wound healing, which impacts patient care. External application of electrical stimulation (ES) has beneficial effects on wound repair and regeneration. The majority of studies to date have explored ES in relation to planktonic microorganisms, yet evidence indicates that bacteria in chronic wounds reside as antibiotic-resistant polymicrobial biofilms, which contribute to impairing wound healing. Culture-independent sequencing techniques have revolutionized our understanding of the skin microbiome and allowed a more accurate determination of microbial taxa and their relative abundance in wounds allowing a greater understanding of the host-microbial interface. Future studies combining the fields of ES, biofilm and microbiome research are necessary to fully elucidate the use of ES in the management of wound infection.
感染对皮肤伤口愈合延迟有显著影响，这对患者护理产生了影响。外部施加电刺激（ES）对伤口修复和再生具有有益作用。迄今为止，大多数研究都探讨了与浮游微生物相关的电刺激，然而有证据表明，慢性伤口中的细菌以耐抗生素的多微生物生物膜形式存在，这会导致伤口愈合受损。不依赖培养的测序技术彻底改变了我们对皮肤微生物群的理解，并使我们能够更准确地确定伤口中微生物分类群及其相对丰度，从而更深入地了解宿主与微生物的界面。未来有必要将电刺激、生物膜和微生物群研究领域结合起来进行研究，以充分阐明电刺激在伤口感染管理中的应用。
