Department of Bioscience, Fukui Prefectural University , 4-1-1 Matsuoka-Kenjojima, Eiheiji-cho, Yoshida-gun, Fukui 910-1195, Japan.
Biomacromolecules. 2017 Apr 10;18(4):1387-1392. doi: 10.1021/acs.biomac.7b00109. Epub 2017 Mar 24.
ε-Poly-l-lysine (ε-PL) is one of the few homopoly(amino-acid)s occurring in nature. ε-PL, which possesses multiple amino groups, is highly soluble in water, where it forms the antimicrobial polycationic chain (PL). Although the high water-solubility is advantageous for the use of ε-PL as a food preservative, it has limited the applicability of ε-PL as a biopolymer plastic. Here, we report on the preparation and availability of a water-insoluble complex formed with PL and an anionic surfactant, bis(2-ethylhexyl) sulfosuccinate (BEHS, is also commercialized as AOT) anion. The PL/BEHS-complex, which is soluble in organic solvents, was successfully used as a coating material for a cellulose acetate membrane to create a water-resistant antimicrobial membrane. In addition, the thermoplastic PL/BEHS-complex was able to be uniformly mixed with polypropylene by heating, resulting in materials exhibiting antimicrobial activities.
ε-聚赖氨酸（ε-PL）是自然界中少数几种存在的均聚（氨基酸）之一。ε-PL 具有多个氨基，高度溶于水，在水中形成抗菌的聚阳离子链（PL）。虽然高水溶性有利于将 ε-PL 用作食品防腐剂，但它限制了 ε-PL 作为生物聚合物塑料的适用性。在这里，我们报告了与 PL 和阴离子表面活性剂双（2-乙基己基）磺基琥珀酸钠（也商业化的 AOT 阴离子）形成的不溶于水的复合物的制备和可用性。PL/BEHS 复合物可溶于有机溶剂，成功地用作醋酸纤维素膜的涂层材料，以制造耐水抗菌膜。此外，热塑性 PL/BEHS 复合物能够通过加热与聚丙烯均匀混合，从而得到具有抗菌活性的材料。
