Department of Mechanical, Materials Engineering College of Engineering and Applied Science, University of Cincinnati , Cincinnati, Ohio 45221, United States.
Division of Solid and Fluid Mechanics Center for Devices and Radiological Health, U.S. Food and Drug Administration , Silver Spring, Maryland 20993, United States.
Nano Lett. 2017 Apr 12;17(4):2532-2538. doi: 10.1021/acs.nanolett.7b00272. Epub 2017 Mar 16.
High-intensity focused ultrasound (HIFU) has gained increasing popularity as a noninvasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nanoparticles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0.0625%, and 0.125%) of gNPs were fabricated. Sonications at acoustic powers of 10, 15, and 20 W were performed for a duration of 16 s using an MR-HIFU system. Temperature rises and lesion volumes were calculated and compared for phantoms with and without gNPs. For an acoustic power of 10 W, the maximum temperature rise increased by 32% and 43% for gNPs concentrations of 0.0625% and 0.125%, respectively, when compared to the 0% gNPs concentration. For the power of 15 W, a lesion volume of 0, 44.5 ± 7, and 63.4 ± 32 mm was calculated for the gNPs concentration of 0%, 0.0625%, and 0.125%, respectively. For a power of 20 W, it was found that the lesion volume doubled and tripled for concentrations of 0.0625% and 0.125% gNPs, respectively, when compared to the concentration of 0% gNPs. We conclude that gNPs have the potential to locally enhance the heating and reduce damage to healthy tissue during tumor ablation using HIFU.
高强度聚焦超声（HIFU）作为一种非侵入性的治疗实体肿瘤的方法，越来越受到关注。然而，在 HIFU 过程中使用高声功率所导致的附带损伤仍然是一个挑战。本研究的目的是评估在 HIFU 过程中使用金纳米粒子（gNPs）来局部增强低功率加热的效用，从而降低附带损伤的可能性。制作了含有组织模拟材料（TMM）和生理相关浓度（0%、0.0625%和 0.125%）gNPs 的水凝胶体模。使用 MR-HIFU 系统，在 10、15 和 20 W 的声功率下进行了 16 s 的声处理。计算并比较了有无 gNPs 的体模的温升和病变体积。与 0% gNPs 浓度相比，当声功率为 10 W 时，gNPs 浓度为 0.0625%和 0.125%时，最大温升分别增加了 32%和 43%。当声功率为 15 W 时，gNPs 浓度为 0%、0.0625%和 0.125%时，计算出的病变体积分别为 0、44.5±7 和 63.4±32mm。当声功率为 20 W 时，与 0% gNPs 浓度相比，发现 0.0625%和 0.125% gNPs 的浓度分别使病变体积增加了一倍和三倍。我们得出结论，gNPs 具有在使用 HIFU 消融肿瘤时局部增强加热和减少对健康组织损伤的潜力。
