Devarakonda Surendra B, Myers Matthew R, Banerjee Rupak K
Department of Mechanical, Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221.
Division of Applied Mechanics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993.
J Biomech Eng. 2018 Aug 1;140(8). doi: 10.1115/1.4040120.
Long procedure times and collateral damage remain challenges in high-intensity focused ultrasound (HIFU) medical procedures. Magnetic nanoparticles (mNPs) and gold nanoparticles (gNPs) have the potential to reduce the acoustic intensity and/or exposure time required in these procedures. In this research, we investigated relative advantages of using gNPs and mNPs during HIFU thermal-ablation procedures. Tissue-mimicking phantoms containing embedded thermocouples (TCs) and physiologically acceptable concentrations (0.0625% and 0.125%) of gNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 s. It was observed that when the concentration of gNPs was doubled from 0.0625% to 0.125%, the temperature rise increased by 80% for a power of 5.2 W. For a fixed concentration (0.0625%), the energy absorption was 1.7 times greater for mNPs than gNPs for a power of 5.2 W. Also, for the power of 14.5 W, the sonication time required to generate a lesion volume of 50 mm3 decreased by 1.4 times using mNPs, compared with gNPs, at a concentration of 0.0625%. We conclude that mNPs are more likely than gNPs to produce a thermal enhancement in HIFU ablation procedures.
在高强度聚焦超声（HIFU）医疗程序中，较长的操作时间和附带损伤仍然是挑战。磁性纳米颗粒（mNPs）和金纳米颗粒（gNPs）有潜力降低这些程序所需的声强和/或暴露时间。在本研究中，我们调查了在HIFU热消融程序中使用gNPs和mNPs的相对优势。含有嵌入式热电偶（TCs）以及生理可接受浓度（0.0625%和0.125%）的gNPs的仿组织体模，在5.2 W、9.2 W和14.5 W的声功率下超声处理30秒。观察到，当gNPs的浓度从0.0625%翻倍至0.125%时，对于5.2 W的功率，温度升高增加了80%。对于固定浓度（0.0625%），在5.2 W的功率下，mNPs的能量吸收比gNPs大1.7倍。此外，对于14.5 W的功率，在浓度为0.0625%时，与gNPs相比，使用mNPs产生50 mm³损伤体积所需的超声处理时间减少了1.4倍。我们得出结论，在HIFU消融程序中，mNPs比gNPs更有可能产生热增强效果。
