Devarakonda Surendra Balaji, Myers Matthew R, Giridhar Dushyanth, Dibaji Seyed Ahmad Reza, Banerjee Rupak Kumar
Department of Mechanical, Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, Ohio, United States of America.
Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America.
PLoS One. 2017 Apr 6;12(4):e0175093. doi: 10.1371/journal.pone.0175093. eCollection 2017.
Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.
高强度聚焦超声（HIFU）消融手术过程中产生的附带损伤和较长的超声处理时间限制了其临床进展。在本研究中，我们调查了使用磁性纳米颗粒（mNPs）是否能够降低消融组织所需的功率，或者在相同功率下缩短手术时间。含有嵌入式热电偶以及生理可接受浓度（0%、0.0047%和0.047%）mNPs的仿组织体模在5.2 W、9.2 W和14.5 W的声功率下超声处理30秒。测定了含和不含mNPs的体模的损伤体积。结果发现，当mNP浓度为0.047%时，获得13 mm³损伤体积所需的功率可减半，形成21 mm³损伤所需的时间减少了五倍。我们得出结论，在使用HIFU进行肿瘤消融时，mNPs有潜力减少对健康组织的损伤并缩短手术时间。
