a Jacobi Medical Center, Department of Pediatrics, Division of Infectious Diseases , Albert Einstein College of Medicine , Bronx , NY , USA.
b Montefiore Medical Center , Department of Pediatrics, Division of Infectious Diseases , Bronx , NY , USA.
Expert Rev Clin Pharmacol. 2017 May;10(5):509-516. doi: 10.1080/17512433.2017.1301205. Epub 2017 Mar 14.
With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program's 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.
目前，联合抗逆转录病毒疗法能够实现持久抑制病毒复制、维持免疫功能和恢复正常预期寿命。而对于感染艾滋病毒的青少年和青年来说，他们在接受抗逆转录病毒治疗时面临着独特的临床和药理学挑战，需要优化治疗效果。本文涵盖了最近的临床试验数据，并借鉴了我们项目 25 年来在治疗围产期和行为感染的青少年方面的经验。为了确保治疗效果，我们提供的抗逆转录病毒药物必须与多学科干预和持续的社会行为支持相结合，以确保治疗依从性并预防病毒耐药性的出现。
