Erdöl Hidayet, Hacioglu Dilek, Kola Mehmet, Türk Adem, Aslan Yakup
Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
J AAPOS. 2017 Apr;21(2):136-140. doi: 10.1016/j.jaapos.2017.03.006. Epub 2017 Mar 10.
To investigate the effect of hemoglobin F (HbF) and hemoglobin A (HbA) levels on development of retinopathy of prematurity (ROP) in premature infants.
In this prospective study, blood samples were collected from the side of the heel of 49 premature infants at postnatal months 0, 1, 2, and 3. HbF and HbA levels were measured in all samples and analyzed statistically. Furthermore, correlation analysis was performed regarding development of ROP, blood transfusion, and HbF and HbA levels.
A total of 49 infants were included. The mean gestational age of the premature infants was 30.9 ± 2.7 weeks (range, 25-35 weeks); mean birth weight, 1542 ± 582 g (range, 520-3240 g). Of the 49 premature infants, stage 1 ROP or above developed in 26 (53%). Mean HbF levels were lower at postnatal months 1 and 2 in premature infants with ROP compared to those without ROP (P = 0.013 and 0.02, respectively); however, mean HbA levels were higher in the infants with ROP than the others (P = 0.034 and 0.029, respectively). Analysis of covariance that ignored transfusion revealed no difference between the means of Hb variants in the infants with and without ROP (P = 0.572 and 0.486).
Blood transfusion significantly altered the levels of HbF and HbA in premature infants, and Hb variants have no direct effect on development of ROP.
探讨血红蛋白F（HbF）和血红蛋白A（HbA）水平对早产儿视网膜病变（ROP）发生发展的影响。
在这项前瞻性研究中，于出生后0、1、2和3个月从49例早产儿足跟侧采集血样。检测所有样本中的HbF和HbA水平并进行统计学分析。此外，对ROP的发生发展、输血情况以及HbF和HbA水平进行相关性分析。
共纳入49例婴儿。早产儿的平均胎龄为30.9±2.7周（范围25 - 35周）；平均出生体重为1542±582克（范围520 - 3240克）。49例早产儿中，26例（53%）发生了1期及以上的ROP。与未发生ROP的早产儿相比，发生ROP的早产儿在出生后1个月和2个月时的平均HbF水平较低（分别为P = 0.013和0.02）；然而，发生ROP的婴儿的平均HbA水平高于其他婴儿（分别为P = 0.034和0.029）。忽略输血因素的协方差分析显示，发生和未发生ROP的婴儿中Hb变异体的均值无差异（P = 0.572和0.486）。
输血显著改变了早产儿的HbF和HbA水平，Hb变异体对ROP的发生发展无直接影响。
