Department of Ophthalmology, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
Department of Pediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
Indian J Ophthalmol. 2023 Nov;71(11):3478-3483. doi: 10.4103/IJO.IJO_274_23.
The objective of this study was to find the association between fetal hemoglobin (HbF) concentration and retinopathy of prematurity (ROP) in preterm infants.
In this observational, prospective, longitudinal study, a total of 410 preterm infants with <36 gestational weeks and <2.5 kg birth weight, who were attending ROP clinic in a tertiary care hospital of central India for 1 year duration were included. Dilated fundus examination was done as per ROP screening guidelines, and ROP was staged as per international classification for retinopathy of prematurity (ICROP) classification, 2021. HbF (%) was measured with high-performance liquid chromatography, and data was analyzed statistically. The relationship between HbF (%) and ROP was evaluated. Those infants who had ROP were further divided into treatment-requiring and non-treatment-requiring groups and HbF was compared in these groups at the first visit and after 1-month follow-up period. The outcome of ROP was studied with HbF levels.
A total of 410 preterm infants were included, out of which 110 infants had ROP (26.8%). Infants with ROP had significantly lower percentage of HbF with gestational age groups and birth weight groups, compared to infants without ROP. Higher percentage of HbF was associated with a lower prevalence of ROP. Higher concentration of HbF was found in the ROP infants who regressed spontaneously without treatment and less concentration was found in those who progressed to a severe disease and those who required treatment. The predictive ability of HbF (%) was 0.976 for ROP.
Low fraction of HbF was found to be significantly associated with the development and progression of ROP.
本研究旨在探讨胎儿血红蛋白（HbF）浓度与早产儿视网膜病变（ROP）之间的关系。
在这项观察性、前瞻性、纵向研究中，共纳入了 410 名胎龄<36 周且出生体重<2.5kg 的早产儿，他们在印度中部一家三级保健医院的ROP 诊所接受了为期 1 年的随访。根据 ROP 筛查指南进行了眼底散瞳检查，并根据国际早产儿视网膜病变分类（ICROP）分类，2021 年对 ROP 进行了分期。使用高效液相色谱法测量了 HbF（%），并进行了统计学分析。评估了 HbF（%）与 ROP 之间的关系。将那些患有 ROP 的婴儿进一步分为需要治疗和不需要治疗的两组，并在第一次就诊时和 1 个月随访期比较这两组的 HbF。研究了 ROP 的结局与 HbF 水平的关系。
共纳入了 410 名早产儿，其中 110 名婴儿患有 ROP（26.8%）。与无 ROP 的婴儿相比，ROP 婴儿的 HbF 百分比在胎龄组和出生体重组中显著较低。较高的 HbF 百分比与 ROP 的患病率较低相关。在自发消退而无需治疗的 ROP 婴儿中发现了较高的 HbF 浓度，而在进展为严重疾病和需要治疗的婴儿中发现了较低的浓度。HbF（%）对 ROP 的预测能力为 0.976。
较低的 HbF 分数与 ROP 的发生和进展显著相关。
