犬钩虫新微卫星的开发及巴西种群的遗传多样性分析。
Development of new microsatellites for the hookworm Ancylostoma caninum and analysis of genetic diversity in Brazilian populations.
作者信息
Rabelo Élida Mara Leite, Miranda Rodrigo Rodrigues Cambraia de, Furtado Luis Fernando Viana, Redondo Rodrigo Aparecido Fernandes, Tennessen Jacob Adam, Blouin Michael Scott
机构信息
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil.
Curso de Ciências Biológicas, Centro de Ciências Agrárias e Biológicas - CBAB, Universidade Estadual Vale do Acaraú, Av. da Universidade 850, campus Betânia, CEP 62040-370 Sobral, Ceará, Brazil.
出版信息
Infect Genet Evol. 2017 Jul;51:24-27. doi: 10.1016/j.meegid.2017.03.008. Epub 2017 Mar 10.
Considering the great efforts towards formulating a vaccine against hookworms, and the concerns about the spread of drug resistance through hookworm populations, it is justified to study the molecular diversity and population genetic structure of these nematodes. This work had the aim to develop microsatellite markers to investigate the genetic structure and the molecular diversity of Brazilian populations of Ancylostoma caninum. Seven microsatellites markers were successfully used to characterize five Brazilian populations. These findings may contribute to a better comprehension of the ecology, patterns of transmission, drug resistances and development of immunotherapeutic strategies in hookworms.
鉴于在研发抗钩虫疫苗方面付出的巨大努力，以及对钩虫种群中耐药性传播的担忧，研究这些线虫的分子多样性和种群遗传结构是合理的。这项工作旨在开发微卫星标记，以研究巴西犬钩虫种群的遗传结构和分子多样性。七个微卫星标记成功用于对五个巴西种群进行特征分析。这些发现可能有助于更好地理解钩虫的生态学、传播模式、耐药性以及免疫治疗策略的开发。
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