Grober Ellen, Wakefield Dorothy, Ehrlich Amy R, Mabie Peter, Lipton Richard B
Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Center on Aging, UConn Health, Farmington, CT, USA.
Alzheimers Dement (Amst). 2017 Feb 24;6:188-195. doi: 10.1016/j.dadm.2017.01.006. eCollection 2017.
This study examined the operating characteristics of two-stage case finding to identify memory impairment and very mild dementia.
Primary care patients underwent two-stage testing and a subsequent diagnostic assessment to assess outcomes. Patients who screen positive for subjective cognitive decline on the Informant Questionnaire on Cognitive Decline in the Elderly undergo memory testing with the Free and Cued Selective Reminding Test with Immediate Recall. Outcomes were determined without access to these data. A split-half design with discovery and confirmatory samples was used.
One hundred seventeen of 563 (21%) patients had dementia and 68 (12%) had memory impairment but not dementia. Operating characteristics were similar in the discovery and confirmatory samples. In the pooled sample, combined, patients with memory impairment or dementia were identified with good sensitivity (72%) and high specificity (90%). Differences in ethnicity, educational level, or age (≤75, >75) did not affect classification accuracy.
Two-stage screening facilitates the efficient identification of older adults with memory impairment or dementia.
本研究考察了两阶段病例筛查法用于识别记忆障碍和极轻度痴呆的操作特性。
初级保健患者接受两阶段测试及后续诊断评估以评定结果。在《老年人认知功能下降知情者问卷》中筛查出主观认知功能下降呈阳性的患者,采用带即时回忆的自由和线索选择性回忆测验进行记忆测试。在无法获取这些数据的情况下确定结果。采用了包含发现样本和验证样本的对半设计。
563名患者中有117名(21%)患有痴呆,68名(12%)有记忆障碍但未患痴呆。发现样本和验证样本的操作特性相似。在合并样本中,记忆障碍或痴呆患者的综合识别具有良好的敏感性(72%)和较高的特异性(90%)。种族、教育水平或年龄(≤75岁、>75岁)的差异不影响分类准确性。
两阶段筛查有助于高效识别有记忆障碍或痴呆的老年人。