用于增强选择性和对半胱氨酸进行显著荧光开启检测的双环化过程和双猝灭机制的编排。
Orchestration of dual cyclization processes and dual quenching mechanisms for enhanced selectivity and drastic fluorescence turn-on detection of cysteine.
作者信息
Tong Hongjuan, Zhao Jianhong, Li Xiangmin, Zhang Yajun, Ma Shengnan, Lou Kaiyan, Wang Wei
机构信息
Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2017 Mar 23;53(25):3583-3586. doi: 10.1039/c6cc09336a.
We reported a new approach to achieve enhanced selectivity with a drastic turn-on fluorescence response for the detection of Cys through dual intramolecular cyclization processes and dual PET and ICT quenching mechanisms by the incorporation of an acrylate and a maleimide group onto two opposite sides of a single coumarin fluorophore.
我们报道了一种新方法，通过在单个香豆素荧光团的两个相对侧引入丙烯酸酯和马来酰亚胺基团，利用双分子内环化过程以及双正电子转移（PET）和分子内电荷转移（ICT）猝灭机制，实现对胱氨酸（Cys）检测的增强选择性和强烈的荧光开启响应。
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