Barnes Danielle, Park K T
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Naval Medical Center San Diego, San Diego, CA, USA.
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Stanford Children's Health, Palo Alto, CA, USA.
Curr Gastroenterol Rep. 2017 Mar;19(3):10. doi: 10.1007/s11894-017-0548-y.
Tremendous acceleration has been made in understanding the gut microbiota in the past decade and, with it, further understanding of the pathologic role of dysbiosis and the use of fecal microbiota transplantation (FMT) as therapy. FMT has been studied in many disease states including the most common indication of Clostridium difficile infection (CDI), though many questions regarding stool donor selection remain.
Though traditionally, one donor has provided stool for one patient, research is underway to explore many donor selection considerations from the use of pooled donor stool to selection of a high diversity donor. It is well-known that dietary intake shapes the gut microbiota and the potential implications of this on FMT donor selection are being explored. Though further high-quality research is needed, optimizing the fecal microbiota inoculum holds great promise.
在过去十年中，我们对肠道微生物群的理解取得了巨大进展，与此同时，对菌群失调的病理作用以及粪便微生物群移植（FMT）作为一种治疗方法的理解也进一步加深。FMT已在多种疾病状态中进行了研究，包括艰难梭菌感染（CDI）这一最常见的适应症，不过关于粪便供体选择仍存在许多问题。
传统上，一名供体为一名患者提供粪便，但目前正在进行研究，以探索许多供体选择方面的考虑因素，从使用混合供体粪便到选择高多样性供体。众所周知，饮食摄入会塑造肠道微生物群，目前正在探索这对FMT供体选择的潜在影响。尽管还需要进一步的高质量研究，但优化粪便微生物接种物前景广阔。
