RHA/Verh和RLA/Verh大鼠中吗啡的阿片受体结合及行为效应
Opiate receptor binding and behavioral effects of morphine in RHA/Verh and RLA/Verh rats.
作者信息
Lazega D, Driscoll P, Frischknecht H R, Siegfreid B, Waser P G
机构信息
Inst. of Pharmacology, Univ. of Zurich, Switzerland.
出版信息
NIDA Res Monogr. 1986;75:485-8.
PMID:2828996
Abstract
Large baseline differences were found in open field activity and rearing behavior between 2 psychogenetically selected rat lines, as well as differences in the effects of peripherally administered morphine (2,4 and 10 mg/kg) on those behaviors and on body temperature. The 2 lines also showed different capacities of tritiated DAGO binding to preparations of striatal membranes.
摘要
在两个经心理遗传学选择的大鼠品系之间，旷场活动和竖毛行为存在较大的基线差异，外周注射吗啡（2、4和10毫克/千克）对这些行为及体温的影响也存在差异。这两个品系还显示出氚标记的DAGO与纹状体膜制剂结合的能力不同。
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