鞘内注射阿片类激动剂对疼痛行为和血流动力学表现的影响
[Effect of opiate agonists administered intrathecally on the behavioral and hemodynamic manifestations of pain].
作者信息
Zaĭtsev A A, Petriaevskaia N V, Khvan A A
出版信息
Farmakol Toksikol. 1988 Jan-Feb;51(1):23-5.
PMID:2834219
Abstract
An agonist of mu-opiate receptors, D-Ala2-Gly-ol5-enkephalin (DAGO, 0.5 mcg), administered intrathecally, was found to inhibit behavioral and hemodynamic reactions induced by thermal and electrical stimulation of conscious male rats. D-Ala2-D-Leu-enkephalin (DADL, 0.5 mcg), acting on delta-receptors, was shown to potentiate nociceptive shifts of arterial blood pressure. Phencyclidine and bremazocine failed to exert any significant effect on the opioidergic mechanisms of the spinal cord.
摘要
鞘内注射μ-阿片受体激动剂D-Ala2-Gly-ol5-脑啡肽（DAGO，0.5微克），可抑制清醒雄性大鼠经热刺激和电刺激诱发的行为和血流动力学反应。作用于δ受体的D-Ala2-D-Leu-脑啡肽（DADL，0.5微克）可增强动脉血压的伤害性变化。苯环己哌啶和布瑞马唑未能对脊髓的阿片能机制产生任何显著影响。
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