Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Pharmacy Unit, Phramongkutklao Hospital, Bangkok, Thailand.
Appl Health Econ Health Policy. 2017 Oct;15(5):669-679. doi: 10.1007/s40258-017-0320-3.
Little was known about the head-to-head comparison of psychometric properties between SF-6D and EQ-5D-5L or the different value sets of EQ-5D-5L. Therefore, this study set out to compare the psychometric properties including agreement, convergent, and known-group validity between the SF-6D and the EQ-5D-5L using the real value sets from Thailand and the UK in patients with chronic diseases.
356 adults taking a medication for at least 3 months were identified from a university hospital in Bangkok, Thailand, between July 2014 and March 2015. Agreement was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots. Convergent validity was evaluated using Spearman's rank correlation coefficients between SF-6D and EQ-5D-5L and EQ-VAS and SF-12v2. For known-groups validity, the Mann-Whitney U test and Kruskal-Wallis test were used to examine the associations between SF-6D and EQ-5D-5L and patient characteristics.
Agreements between the SF-6D and the EQ-5D-5L using Thai and UK value sets were fair, with ICCs of 0.45 and 0.49, respectively. Bland-Altman plots showed that the majority of the SF-6D index scores were lower than the EQ-5D-5L index scores. Both the EQ-5D-5L value sets were more related to the EQ-VAS and physical health, while the SF-6D was more associated with mental health. Both EQ-5D-5L value sets were more sensitive than the SF-6D in discriminating patients with different levels of more known groups except for adverse drug reactions.
The SF-6D and both EQ-5D-5L value sets appeared to be valid but sensitive to different outcomes in Thai patients with chronic diseases.
SF-6D 与 EQ-5D-5L 的心理测量特性，以及 EQ-5D-5L 的不同效价轴之间的头对头比较鲜为人知。因此，本研究旨在使用来自泰国和英国的真实效价轴比较慢性病患者 SF-6D 与 EQ-5D-5L 的心理测量特性，包括一致性、收敛性和已知组有效性。
2014 年 7 月至 2015 年 3 月，从泰国曼谷的一所大学医院中确定了 356 名至少服用 3 个月药物的成年人。通过组内相关系数（ICC）和 Bland-Altman 图评估一致性。使用 Spearman 秩相关系数评估收敛有效性，SF-6D 与 EQ-5D-5L 以及 EQ-VAS 和 SF-12v2 之间的相关性。对于已知组有效性， Mann-Whitney U 检验和 Kruskal-Wallis 检验用于检验 SF-6D 与 EQ-5D-5L 与患者特征之间的关联。
使用泰国和英国效价轴的 SF-6D 与 EQ-5D-5L 的一致性为中等，ICC 分别为 0.45 和 0.49。Bland-Altman 图显示，大多数 SF-6D 指数得分低于 EQ-5D-5L 指数得分。两个 EQ-5D-5L 效价轴都与 EQ-VAS 和身体健康更相关，而 SF-6D 则与心理健康更相关。除了药物不良反应外，两个 EQ-5D-5L 效价轴在区分不同水平的更多已知组患者方面都比 SF-6D 更敏感。
SF-6D 和两个 EQ-5D-5L 效价轴在泰国慢性病患者中似乎是有效的，但对不同的结果敏感。
