Saw Swee Hock School of Public Health, National University of Singapore, 12 Sciene Drive 2, Singapore, 117549, Singapore.
Pharmerit International, Marten Meesweg 107, 3068 AV, Rotterdam, The Netherlands.
Pharmacoeconomics. 2020 Feb;38(2):159-170. doi: 10.1007/s40273-019-00854-w.
Our aim was to systematically review published evidence on the construct validity, test-retest reliability and responsiveness of generic preference-based measures (PBMs) used in East and South-East Asia.
This systematic review was guided by the COSMIN guideline. A literature search on the MEDLINE, EMBASE, PsycINFO and PubMed databases up to August 2019 was conducted for measurement properties validation papers of the EuroQol-5 Dimensions (EQ-5D), Short Form-6 Dimensions (SF-6D), Health Utilities Index (HUI), Quality of Well-Being (QWB), 15-Dimensional (15D) and Assessment of Quality of Life (AQOL) in East and South-East Asian countries. Included papers were disaggregated into individual studies whose results and quality of design were rated separately. The population-specific measurement properties (construct validity, test-retest reliability and responsiveness) of each PBM were assessed separately using relevant studies. The overall methodological quality of the studies used in each of the assessments was also rated.
A total of 79 papers containing 1504 studies were included in this systematic review. The methodological quality was 'very good' or 'adequate' for the majority of the construct validity studies (99%) and responsiveness studies (61%), but for only a small portion of the test-retest reliability studies (23%). EQ-5D was most widely assessed and was found to have 'sufficient' construct validity and responsiveness in many populations, while the SF-6D and EuroQol-Visual Analog Scale (EQ-VAS) exhibited 'inconsistent' construct validity in some populations. Scarce evidence was available on HUI and QWB, but current evidence supported the use of HUI.
This systematic review provides a summary of the quality of existing generic PBMs in Asian populations. The current evidence supports the use of EQ-5D as the preferred choice when a generic PBM is needed, and continuous testing of all PBMs in the region.
本研究旨在系统地回顾已发表的东亚和东南亚地区通用偏好测量量表（PBM）的构建效度、重测信度和反应度的证据。
本系统评价遵循 COSMIN 指南。对 MEDLINE、EMBASE、PsycINFO 和 PubMed 数据库进行了截至 2019 年 8 月的文献检索，以获取东亚和东南亚国家使用的欧洲五维健康量表（EQ-5D）、简短健康量表-6 维度（SF-6D）、健康效用指数（HUI）、健康相关生活质量量表（QWB）、15 维度量表（15D）和生活质量评估量表（AQOL）的测量特性验证研究。纳入的文献被分为单独的研究，分别对其结果和设计质量进行评分。使用相关研究分别评估每种 PBM 的特定人群的测量特性（构建效度、重测信度和反应度）。还对每项评估中使用的研究的总体方法学质量进行了评分。
本系统评价共纳入 79 篇文献，包含 1504 项研究。大多数构建效度研究（99%）和反应度研究（61%）的方法学质量为“非常好”或“充分”，但仅有一小部分重测信度研究（23%）的方法学质量为“非常好”或“充分”。EQ-5D 评估最为广泛，在许多人群中被认为具有“充分”的构建效度和反应度，而 SF-6D 和 EQ-VAS 在一些人群中表现出“不一致”的构建效度。HUI 和 QWB 的证据较少，但现有证据支持 HUI 的使用。
本系统评价总结了亚洲人群中现有通用 PBM 的质量。现有证据支持在需要通用 PBM 时首选使用 EQ-5D，并在该地区持续测试所有 PBM。
