Sakthong Phantipa, Sonsa-Ardjit Nontapat, Sukarnjanaset Pattarin, Munpan Wipaporn
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Qual Life Res. 2015 Dec;24(12):3015-22. doi: 10.1007/s11136-015-1038-z. Epub 2015 Jun 6.
Due to the problem of high ceiling effects of the EQ-5D-3L, the EQ-5D-5L was developed. However, little was known about the full psychometric properties of the EQ-5D-5L. Thus, this study aimed to evaluate its practicality, reliability, validity, and responsiveness in Thai patients with chronic diseases.
One thousand one hundred and fifty-six adults taking a medicine at least 3 months were identified from three university hospitals in Bangkok, Thailand, between July 2014 and March 2015. Practicality was evaluated by administration times and ceiling effects. Test-retest reliability was assessed using weighted kappa and intraclass correlation coefficients (ICCs). Validity was tested with correlations between the EQ-5D-5L and WHOQoL-BREF and SF-12v2, and known-groups validity. Responsiveness was measured with standardized effect sizes (SES).
The mean administration time was approximately 2 min, and the ceiling effect of the EQ-5D-5L index was 13.6 %. The weighted kappa values and ICC of the EQ-5D-5L were 0.48-0.61 and 0.82, respectively. Similar dimensions of the EQ-5D-5L had higher correlations with those of WHOQoL-BREF and SF-12v2. As expected, elderly, female, low-educated, unemployed, higher number of comorbidities and medicines, patients' perception of poor disease control, and having an adverse drug reaction tended to have poorer EQ-5D-5L scores. The SES of EQ-5D-5L index and EQ-VAS were considered small (0.33-0.42) for the improved group. For the worsened group, the SES of the EQ-5D-5L index were considered small (-0.29) but that of the EQ-VAS considered large (-0.82).
The EQ-5D-5L was practical, reliable, valid, and responsive in Thai patients with chronic diseases.
由于EQ-5D-3L存在天花板效应问题，因此开发了EQ-5D-5L。然而，对于EQ-5D-5L完整的心理测量特性知之甚少。因此，本研究旨在评估其在泰国慢性病患者中的实用性、可靠性、有效性和反应性。
2014年7月至2015年3月期间，从泰国曼谷的三家大学医院中确定了1156名服用药物至少3个月的成年人。通过给药时间和天花板效应评估实用性。使用加权kappa和组内相关系数（ICC）评估重测可靠性。通过EQ-5D-5L与WHOQoL-BREF和SF-12v2之间的相关性以及已知组效度来测试有效性。用标准化效应量（SES）测量反应性。
平均给药时间约为2分钟，EQ-5D-5L指数的天花板效应为13.6%。EQ-5D-5L的加权kappa值和ICC分别为0.48 - 0.61和0.82。EQ-5D-5L的相似维度与WHOQoL-BREF和SF-12v2的维度具有更高的相关性。正如预期的那样，老年人、女性、低学历、失业、合并症和药物数量较多、患者对疾病控制不佳的感知以及有药物不良反应的患者往往EQ-5D-5L得分较低。对于改善组，EQ-5D-5L指数和EQ-VAS的SES被认为较小（0.33 - 0.42）。对于恶化组，EQ-5D-5L指数的SES被认为较小（-0.29），但EQ-VAS的SES被认为较大（-0.82）。
EQ-5D-5L在泰国慢性病患者中具有实用性、可靠性、有效性和反应性。
