A V A, Zaslavskaya E L, Soboleva A V, Baranova E I, Listopad O V, Nifontov S E, Nrady A O, Shlyakhto E V
Pavlov First Saint-Petersburg State Medical University, Russian.
Federal Almazov North-West Medical Research Centere, Saint-Petersburg, Russian.
Kardiologiia. 2016 Jun;56(6):41-45. doi: 10.18565/cardio.2016.6.17-22.
To evaluate serum galectin 3 and to determine the potential clinical value of this parameter in patients with atrial fibrillation - AF (paroxysmal and persistent) and metabolic syndrome (MS).
We examined 100 patients with MS (50 with paroxysmal or persistent AF and 50 without arrhythmia) and 50 healthy persons. Serum galectin 3 measured by ELISA method, ECHO cardiography was performed to all examined persons.
Galectin 3 in patients with MS and AF was higher, than in patients with MS without arrhythmia and much more higher than galectin 3 in healthy persons 0,72 (0,44;1,36), 0,44 (0,42;1,22) and 0,32 (0,28;0,42) ng/ml (<0,01). In patients with persistent AF levels of galectin 3 is higher than in patients with paroxysmal AF. Positive correlation between the levels of galectin 3 and duration arrhythmia was revealed (r=0,301; p<0,01). Higher level of galectin 3 was revealed in patients with frequent paroxysms of AF and ineffective antiarrhythmic therapy.
Marker of myocardial fibrosis serum galectin 3 in patients with atrial fibrillation and metabolic syndrome is higher than in patients with the metabolic syndrome, without this arrhythmia and higher than in healthy controls. In patients with persistent AF level of galectin 3 was higher than in patients with paroxysmal AF.
评估血清半乳糖凝集素3，并确定该参数在房颤（阵发性和持续性）及代谢综合征（MS）患者中的潜在临床价值。
我们检查了100例MS患者（50例阵发性或持续性房颤患者和50例无心律失常患者）以及50名健康人。采用ELISA法测定血清半乳糖凝集素3，对所有受检者进行超声心动图检查。
MS合并房颤患者的半乳糖凝集素3水平高于无心律失常的MS患者，且远高于健康人的半乳糖凝集素3水平，分别为0.72（0.44；1.36）、0.44（0.42；1.22）和0.32（0.28；0.42）ng/ml（<0.01）。持续性房颤患者的半乳糖凝集素3水平高于阵发性房颤患者。半乳糖凝集素3水平与心律失常持续时间呈正相关（r = 0.301；p < 0.01）。房颤发作频繁且抗心律失常治疗无效的患者半乳糖凝集素3水平更高。
房颤合并代谢综合征患者的心肌纤维化标志物血清半乳糖凝集素3高于无该心律失常的代谢综合征患者，且高于健康对照。持续性房颤患者的半乳糖凝集素3水平高于阵发性房颤患者。
