Almazov National Medical Research Centre, Institute of Endocrinology, Metabolic Syndrome Laboratory, 197341 St. Petersburg, Russia.
Department of Internal Diseases №1, Department of Surgery №2, Pavlov University, 197022 St. Petersburg, Russia.
Int J Mol Sci. 2020 Aug 8;21(16):5689. doi: 10.3390/ijms21165689.
The aim of this study was to determine the concentration of galectin-3, PINP and PIIINP in patients with metabolic syndrome (MS) and atrial fibrillation (AF) with an assessment of the relationship with severity of left atrium fibrosis. A total of 480 subjects were included in the case-control study: MS patients ( = 337), 176 of whom had AF, 72 patients with AF without MS and 71 healthy subjects. Galectin-3, PINP and PIIINP blood concentrations and metabolic parameters were compared with the severity of left atrium fibrosis, measured by CARTO3. Galectin-3 in AF and MS patients is higher than in MS without AF and in healthy subjects (10.3 (4.8-15.4), 5.1 (4.3-8.8), 3.2 (2.4-4.2) ng/mL, < 0.0001). Galectin-3 serum concentration in AF patients with MS is higher than in patients without MS: 10.3 (4.8-15.4), 6.8 (5.2-8.1) ng/mL, = 0.0001. PINP and PIIINP concentration were higher in patients with AF and MS than in MS without AF: 3499.1 (2299.2-4567.3), 2130.9 (1425.3-2861.8) pg/mL, < 0.0001, 94.9 (64.8-123.5), 57.6 (40.5-86.9) ng/mL, < 0.0001. Galectin-3 correlates with PINP (r = 0.496, < 0.001) and PIIINP concentration ( = 0.451, < 0.0001). The correlation between galectin-3, PINP and the severity of left atrium fibrosis was found (r = 0.410, < 0.001; = 0.623, < 0.001). Galectin-3 higher than 12.6 ng/mL increased the risk of AF more than five-fold. High galectin-3, PINP and PIIINP concentrations were associated with heart remodeling in MS patients and increased the risk of AF.
本研究旨在确定代谢综合征（MS）合并心房颤动（AF）患者中半乳糖凝集素-3（Galectin-3）、PINP 和 PIIINP 的浓度，并评估其与左心房纤维化严重程度的关系。共纳入 480 例病例对照研究患者：MS 患者（n=337），其中 176 例合并 AF，72 例 MS 合并 AF 患者，71 例健康对照者。比较 Galectin-3、PINP 和 PIIINP 血浓度和代谢参数与左心房纤维化严重程度的关系，左心房纤维化严重程度采用 Carto3 测量。AF 和 MS 患者的 Galectin-3 高于 MS 无 AF 患者和健康对照者（10.3（4.8-15.4）、5.1（4.3-8.8）、3.2（2.4-4.2）ng/ml， < 0.0001）。MS 合并 AF 患者的 Galectin-3 血清浓度高于 MS 无 AF 患者：10.3（4.8-15.4）、6.8（5.2-8.1）ng/ml， = 0.0001。AF 和 MS 患者的 PINP 和 PIIINP 浓度高于 MS 无 AF 患者：3499.1（2299.2-4567.3）、2130.9（1425.3-2861.8）pg/ml， < 0.0001，94.9（64.8-123.5）、57.6（40.5-86.9）ng/ml， < 0.0001。Galectin-3 与 PINP（r = 0.496， < 0.001）和 PIIINP 浓度（ = 0.451， < 0.0001）相关。Galectin-3、PINP 与左心房纤维化严重程度之间存在相关性（r = 0.410， < 0.001； = 0.623， < 0.0001）。Galectin-3 水平高于 12.6ng/ml 时，AF 风险增加 5 倍以上。高 Galectin-3、PINP 和 PIIINP 浓度与 MS 患者的心脏重构相关，增加了 AF 的风险。
