半乳糖凝集素-3：一种检测阵发性心房颤动的生化标志物？

Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?

作者信息

Selcoki Yusuf, Aydin H İbrahim, Celik Tugrul H, Isleyen Ahmet, Erayman Ali, Demircelik M Bora, Demirin Hilmi, Kosus Aydin, Eryonucu Beyhan

机构信息

出版信息

Clin Invest Med. 2016 Dec 1;39(6):27528.

PMID:27917818

Abstract

PURPOSE

Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF.

METHODS

Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age- and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA).

RESULTS

Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p< 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2±3.0 mm vs. 39.6±3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p= 0.001).

CONCLUSION

Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF.

摘要

目的

心房颤动（AF）是最常见的心律失常形式。AF会导致心房电重构和纤维化；然而，其机制仍知之甚少。半乳糖凝集素-3是心脏纤维化的潜在介质。本研究旨在探讨血清半乳糖凝集素-3水平与阵发性AF之间的关系。

方法

本研究纳入了46例阵发性AF且左心室收缩功能保留的患者，以及38例年龄和性别匹配的对照者。采用酶联免疫吸附测定（ELISA）分析血清半乳糖凝集素-3水平。

结果

与对照组相比，阵发性AF患者的血清半乳糖凝集素-3水平（中位数1.38 ng/mL；1.21 ng/mL - 1.87 ng/mL；p < 0.001）显著升高。阵发性AF患者的左心房直径显著更大（41.2±3.0 mm对39.6±3.3 mm）。发现阵发性AF患者的左心房直径与血清半乳糖凝集素-3水平显著相关（r = 0.378，p = 0.001）。