用于鉴定抗体表位的支链β-(1,3)-葡聚糖的自动化聚糖组装
Automated glycan assembly of branched β-(1,3)-glucans to identify antibody epitopes.
作者信息
Weishaupt M W, Hahm H S, Geissner A, Seeberger P H
机构信息
Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
出版信息
Chem Commun (Camb). 2017 Mar 23;53(25):3591-3594. doi: 10.1039/c7cc00520b.
β-(1,3)-Glucans exhibit immunomodulatory and anti-tumor effects. Since the isolation of pure β-(1,3)-glucan oligosaccharides from natural sources is complicated, especially when certain branching patterns are desired, chemical synthesis is frequently the only means of accessing these molecules. We report the iterative automated glycan assembly (AGA) of conjugation-ready linear and branched β-(1,3)-glucan oligosaccharides.
β-(1,3)-葡聚糖具有免疫调节和抗肿瘤作用。由于从天然来源分离纯的β-(1,3)-葡聚糖寡糖很复杂，特别是当需要特定分支模式时，化学合成常常是获得这些分子的唯一方法。我们报道了可用于偶联的线性和分支β-(1,3)-葡聚糖寡糖的迭代自动化聚糖组装（AGA）。
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