Wang Dan, Zhang Kuan, Jia Luhan, Zhang Danting, Zhang Yue, Cheng Yujia, Lin Chang, Wang Bo
State Key Lab of Marine Resource Utilisation in South China Sea, Hainan University, 58# Renmin AVE., Haikou 570228, PR China.
Org Biomol Chem. 2017 Apr 18;15(16):3427-3434. doi: 10.1039/c7ob00270j.
Presented here is the first example of synthesizing an array of primary-, secondary-, and tertiary-α-ketoamides with a non-metal catalyst nBuNI from methyl ketones and inexpensive readily available amine/ammonium salts; the reactions proceeded smoothly under mild conditions, TBHP was used as an oxidant and the corresponding α-ketoamides were afforded in moderate to excellent yields.
本文展示了首例使用非金属催化剂正丁基碘化氮（nBuNI），由甲基酮与廉价易得的胺/铵盐合成一系列伯、仲和叔α-酮酰胺的实例；反应在温和条件下顺利进行，使用叔丁基过氧化氢（TBHP）作为氧化剂，相应的α-酮酰胺以中等至优异的产率得到。
