College of Life Sciences and Biotechnology, Dalian University , Dalian, China.
ACS Appl Mater Interfaces. 2017 Apr 5;9(13):11337-11344. doi: 10.1021/acsami.6b15247. Epub 2017 Mar 21.
Multidrug resistance (MDR) greatly impedes the therapeutic efficacy of chemotherapeutic agents. Overexpression of ATP-binding cassette (ABC) transporters, such as P-gp, on the surface of tumor cells is a major mechanism in MDR. In this study, we fabricated manganese dioxide (MnO)/doxorubicin (DOX)-loaded albumin nanoparticles (BMDN) for magnetic resonance imaging and reversing MDR in resistant tumor. BMDN facilitated the delivery of DOX into MDR tumor cells through their MDR reversal effects including enhanced cellular uptake, reduced drug efflux, and decreased hypoxic tumor microenvironment. BMDN also acted as an effective MRI contrast agent, thereby causing good in vitro and in vivo T-weighted imaging.
多药耐药（MDR）极大地阻碍了化疗药物的治疗效果。肿瘤细胞表面 ATP 结合盒（ABC）转运蛋白的过度表达是 MDR 的主要机制之一。在本研究中，我们制备了载有二氧化锰（MnO）/阿霉素（DOX）的白蛋白纳米颗粒（BMDN），用于磁共振成像和逆转耐药肿瘤的多药耐药性。BMDN 通过其 MDR 逆转作用促进 DOX 递送至耐药肿瘤细胞，包括增强细胞摄取、减少药物外排和降低缺氧肿瘤微环境。BMDN 还可作为一种有效的 MRI 对比剂，从而在体外和体内引起良好的 T 加权成像。
