Tuyns A J, Haelterman M, Kaaks R
Division of Epidemiology and Biostatistics, International Agency for Research on Cancer, Lyon, France.
Nutr Cancer. 1987;10(4):181-96. doi: 10.1080/01635588709513956.
A case-control study was carried out in the populations of two Belgian provinces that differed in food consumption habits, particularly fat intake. There were 453 colonic and 365 rectal cancer cases and 2,851 population controls. There were no significant differences in the average intake of the major nutrients, with the exception of carbohydrates; patients had a larger intake, limited to oligosaccharides. In both provinces, in males and females having cancer of the colon or the rectum, the intake of linoleic acid was lower than among controls; for dietary fibers, a smaller intake was observed among patients in one province. The relative risks were computed for four levels of daily intake of each nutrient. A positive trend was found for oligosaccharides in all subgroups, and a negative trend was found for polysaccharides, the latter for colon cancer patients only. There was a constant and significant negative trend for linoleic acid, with a similar negative trend for dietary fiber. None of these trends were affected by further adjustment for total calorie intake. For several vitamins and minerals, less marked, less constant effects were observed. They tended to be negative for vitamin B1, vitamin B6, and iron; they were positive for retinol and vitamin B2.
在比利时两个食物消费习惯不同，尤其是脂肪摄入量不同的省份的人群中开展了一项病例对照研究。共有453例结肠癌和365例直肠癌病例以及2851名人群对照。除碳水化合物外，主要营养素的平均摄入量没有显著差异；患者摄入量较大，但仅限于低聚糖。在两个省份中，患有结肠癌或直肠癌的男性和女性体内，亚油酸的摄入量均低于对照组；在一个省份中，患者的膳食纤维摄入量较少。计算了每种营养素每日摄入量四个水平的相对风险。在所有亚组中低聚糖呈现出正趋势，多糖呈现出负趋势，后者仅针对结肠癌患者。亚油酸呈现出持续且显著的负趋势，膳食纤维也呈现出类似的负趋势。这些趋势均未因对总热量摄入进行进一步调整而受到影响。对于几种维生素和矿物质，观察到的影响不太显著且不太稳定。它们对维生素B1、维生素B6和铁往往呈负影响；对视黄醇和维生素B2呈正影响。
