生活方式与结直肠癌：病例对照研究。
Lifestyle and colorectal cancer: A case-control study.
机构信息
Department of Medical Informatics, School of Medicine, Tokai University, Bohseidai, Isehara, 259-1193, Kanagawa, Japan.
出版信息
Environ Health Prev Med. 1998 Oct;3(3):146-51. doi: 10.1007/BF02931705.
A case-control study has been conducted to investigate the relationship between lifestyle and risk of colorectal cancer. Cases are one hundred patients diagnosed with colon and rectal cancer in Tokai University Hospital between 1986 and 1994. Three controls per case were individually matched by age, sex, local areas and date of health checkups at the Automated Multi-phasic Health Testing and Services (AMHTS ) Center of the hospital. The results were analyzed by multi-factorial logistic regression models. Positive history of maternal cancer, large consumption of alcohol, frequent consumption of potato products and white-collar job were predominant risk factors while frequent intake of seaweed was a protective factor. Frequent intakes of dairy foods and lack of exercise showed no significant tendency to increase risk of colorectal cancer. Smoking habits, intakes of meat and egg were shown not to be related to this disease. These findings suggest that family history of cancer and dietary factors play a key role in causation and prevention of colorectal cancer.
一项病例对照研究调查了生活方式与结直肠癌风险之间的关系。病例为 1986 年至 1994 年间在东海大学医院诊断为结肠癌和直肠癌的 100 名患者。每个病例匹配 3 名对照，通过年龄、性别、局部地区和医院自动化多相健康检查和服务（AMHTS）中心的体检日期进行匹配。结果通过多因素逻辑回归模型进行分析。阳性的母亲癌症史、大量饮酒、经常食用土豆制品和白领工作是主要的危险因素，而经常食用海藻则是一个保护因素。经常摄入乳制品和缺乏运动与结直肠癌的风险增加没有明显的趋势。吸烟习惯、肉类和蛋类的摄入与该疾病无关。这些发现表明，癌症家族史和饮食因素在结直肠癌的发病和预防中起着关键作用。
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