头孢曲松Etest法检测对甲氧西林敏感的金黄色葡萄球菌的非敏感性及时间杀菌反应。
Ceftriaxone Etest non-susceptible methicillin susceptible Staphylococcus aureus time-kill responses.
作者信息
Bremmer Derek N, Balada-Llasat Joan-Miquel, Goff Debra A, Bauer Karri A
机构信息
Department of Pharmacy, The Ohio State University Wexner Medical Center, 410 W 10th Ave Columbus, OH, 43210, USA.
Department of Pathology, The Ohio State University Medical Center, 410 W 10th Ave Columbus, OH, 43210, USA.
出版信息
Diagn Microbiol Infect Dis. 2017 Jun;88(2):192-194. doi: 10.1016/j.diagmicrobio.2017.02.019. Epub 2017 Mar 2.
We determined the correlation between Etest and BMD MICs with bactericidal activity in MSSA blood isolates. Ceftriaxone was bactericidal in 36% and 9% of isolates exposed to the Etest and BMD MIC, respectively. With the sub-optimal activity of ceftriaxone, the Etest MIC may be a conservative method in identifying clinical utility.
我们确定了Etest最低抑菌浓度（MIC）与耐甲氧西林金黄色葡萄球菌（MSSA）血源分离株杀菌活性之间的相关性。头孢曲松分别对36%和9%的暴露于Etest和BMD MIC的分离株具有杀菌作用。鉴于头孢曲松活性欠佳，Etest MIC可能是一种用于确定临床效用的保守方法。
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