Ruiz-Veguilla Miguel, Moreno-Granados Josefa, Salcedo-Marin Maria D, Barrigon Maria L, Blanco-Morales Maria J, Igunza Evelio, Cañabate Anselmo, Garcia Maria D, Guijarro Teresa, Diaz-Atienza Francisco, Ferrin Maite
Grupo Psicosis y Neurodesarrollo, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Unidad de Hospitalizacion de Salud Mental, Sevilla, Spain.
Departamento de Psiquiatría, ISS Fundación Jiménez Díaz, Universidad Autónoma, Centro de Investigación en Salud Mental (CIBERSAM), Madrid, Spain.
Braz J Psychiatry. 2017 Jan-Mar;39(1):28-35. doi: 10.1590/1516-4446-2015-1807. Epub 2016 Jan 9.
: Brain maturation differs depending on the area of the brain and sex. Girls show an earlier peak in maturation of the prefrontal cortex. Although differences between adult females and males with schizophrenia have been widely studied, there has been less research in girls and boys with psychosis. The purpose of this study was to examine differences in verbal and visual memory, verbal working memory, auditory attention, processing speed, and cognitive flexibility between boys and girls.
: We compared a group of 80 boys and girls with first-episode psychosis to a group of controls.
: We found interactions between group and sex in verbal working memory (p = 0.04) and auditory attention (p = 0.01). The female controls showed better working memory (p = 0.01) and auditory attention (p = 0.001) than males. However, we did not find any sex differences in working memory (p = 0.91) or auditory attention (p = 0.93) in the psychosis group.
: These results are consistent with the presence of sex-modulated cognitive profiles at first presentation of early-onset psychosis.
大脑成熟情况因脑区和性别而异。女孩的前额叶皮质成熟峰值出现得更早。虽然成年精神分裂症女性和男性之间的差异已得到广泛研究，但针对患有精神病的女孩和男孩的研究较少。本研究的目的是检验男孩和女孩在言语和视觉记忆、言语工作记忆、听觉注意力、处理速度和认知灵活性方面的差异。
我们将一组80名首次发作精神病的男孩和女孩与一组对照组进行了比较。
我们发现言语工作记忆（p = 0.04）和听觉注意力（p = 0.01）存在组间与性别的交互作用。女性对照组在工作记忆（p = 0.01）和听觉注意力（p = 0.001）方面表现优于男性。然而，在精神病组中，我们未发现工作记忆（p = 0.91）或听觉注意力（p = 0.93）存在任何性别差异。
这些结果与早发性精神病首次发作时存在性别调节的认知特征一致。
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