Lesueur Paul, Chevalier François, Stefan Dinu, Habrand Jean-Louis, Lerouge Delphine, Gervais Radj
Radiotherapy Unit, Centre François Baclesse, Caen - France.
Laboratory for Research with Accelerated Heavy Ions, Institute of Cellular and Molecular Radiation Biology, CEA-GANIL, Caen - France.
Tumori. 2017 May 12;103(3):217-222. doi: 10.5301/tj.5000616. Epub 2017 Mar 3.
The abscopal effect is a rare phenomenon in radiotherapy, leading to impressive tumor regression outside the radiotherapy field. In this article we describe the occurrence of a postradiotherapy abscopal effect in an 89-year-old patient suffering from a metastatic neuroendocrine large-cell thymic carcinoma, the first case of the abscopal effect related to a thymic carcinoma reported in the literature. Along with the description of this case, we discuss and review the main potential mechanisms of bystander and abscopal effects in solid tumors so as to enable clinicians to identify and control these effects more resourcefully in the age of immunotherapy and stereotactic radiotherapy.
远隔效应是放射治疗中一种罕见的现象，可导致放疗野之外的肿瘤出现显著消退。在本文中，我们描述了一名89岁转移性神经内分泌大细胞胸腺癌患者放疗后发生远隔效应的情况，这是文献中报道的首例与胸腺癌相关的远隔效应病例。在描述该病例的同时，我们讨论并综述了实体瘤中旁效应和远隔效应的主要潜在机制，以便临床医生在免疫治疗和立体定向放疗时代能更有效地识别和控制这些效应。
