Kareff Samuel A, Lischalk Jonathan W, Krochmal Rebecca, Kim Chul
Department of Graduate Medical Education, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
Department of Radiation Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
J Med Case Rep. 2020 Oct 4;14(1):177. doi: 10.1186/s13256-020-02512-8.
The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role.
We report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion.
To our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors.
早在20世纪50年代就已描述了远隔效应，当时未接受治疗的肿瘤在对未治疗的远处部位进行放射治疗后出现反应。尽管越来越多的证据表明消融放疗后抗原表达增加可能起作用，但这种对局部治疗的整体反应的潜在机制仍不清楚。
我们报告了一例69岁的非裔美国女性，有转移性典型肺类癌病史且有多个肺结节，在对寡进展性左下叶病变进行立体定向体部放射治疗后，未治疗的左上叶结节大小显著减小。
据我们所知，本报告描述了典型肺类癌中首例远隔效应病例。需要进一步研究导致这一发现的机制以及放疗与癌症免疫疗法联合在肺类癌肿瘤患者中的作用。
