Institute of Photomedicine, Shanghai Skin Disease Hospital; The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200443, China.
Curr Med Chem. 2018;25(25):2938-2953. doi: 10.2174/0929867324666170314143335.
Due to the good biocompatibility, biodegradability, facile surface functionalization and high water solubility, Bovine serum albumin has gain increasing attention in the nanomedicine.
Despite there are many reviews on albumin based nanoparticles, most of them focus on one aspect of the albumin functionality, e.g., drug delivery, cancer theranostics or half-life extension in vivo. This review aims to comprehensively summary bovine serum albumin as a versatile platform in the applications of cancer imaging and therapy.
We review the extensive applications of bovine serum albumin in drug carrier, surface engineering and biomimetic synthesis for cancer imaging and therapy.
Based on the studies reviewed, variety of in vitro and in vivo studies show good performance of bovine serum albumin as the drug carrier, surface modification agent and biomimetic template in cancer imaging and therapy. Nevertheless, there are still some issues to be solved, e.g., the technological parameters for enhancing the drug loading efficiency and controlling drug release, optimizing surface modification process to provide more stable nanoagents, investigation of the biomimetic mechanism, in-depth study of their toxicity, further exploring their bioapplications, etc.
由于良好的生物相容性、可生物降解性、易于表面功能化和高水溶性，牛血清白蛋白在纳米医学中受到越来越多的关注。
尽管有许多关于基于白蛋白的纳米粒子的综述，但它们大多数集中在白蛋白功能的一个方面，例如药物传递、癌症治疗或体内半衰期延长。本综述旨在全面总结牛血清白蛋白作为癌症成像和治疗中多功能平台的应用。
我们综述了牛血清白蛋白在药物载体、表面工程和仿生合成方面在癌症成像和治疗中的广泛应用。
基于综述的研究，大量的体外和体内研究表明，牛血清白蛋白作为药物载体、表面修饰剂和仿生模板在癌症成像和治疗中具有良好的性能。然而，仍有一些问题需要解决，例如提高药物负载效率和控制药物释放的技术参数、优化表面修饰过程以提供更稳定的纳米制剂、研究仿生机制、深入研究其毒性、进一步探索其生物应用等。
