Meganck Reitske, Desmet Mattias, Bockting Claudi, Inslegers Ruth, Truijens Femke, De Smet Melissa, De Geest Rosa, Van Nieuwenhove Kimberly, Hennissen Vicky, Hermans Goedele, Loeys Tom, Norman Ufuoma Angelica, Baeken Chris, Vanheule Stijn
Department of Psychoanalysis and Clinical Consulting, Faculty of Psychology and Educational Sciences, Ghent University, Henri Dunantlaan 2, Ghent, 9000, Belgium.
Department of Clinical Psychology, Social and Behavioral Sciences, Universiteit Utrecht, Heidelberglaan 1, Utrecht, 3584 CS, Netherlands.
Trials. 2017 Mar 14;18(1):126. doi: 10.1186/s13063-017-1867-x.
Major depressive disorder is a leading cause of disease burden worldwide, indicating the importance of effective therapies. Outcome studies have shown overall efficacy of different types of psychotherapy across groups, yet large variability within groups. Although patient characteristics are considered crucial in understanding outcome, they have received limited research attention. This trial aims at investigating the interaction between therapeutic approach (pre-structured versus explorative) and the personality style of patients (dependent versus self-critical), which is considered a core underlying dimension of depressive pathology.
METHODS/DESIGN: This study is a pragmatic stratified (dependent and self-critical patients) parallel trial with equal randomization (allocation 1:1) conducted in Flanders, Belgium. One hundred and four patients will be recruited and randomized to either 16-20 sessions of cognitive behavioral therapy for depression (pre-structured approach) or 16-20 sessions of short-term psychodynamic psychotherapy for depression (explorative approach) conducted by trained psychotherapists in private practices. The primary outcome is the severity of depression as measured by the Hamilton Rating Scale for Depression at completion of therapy. Secondary outcome measures include self-reported depressive and other symptoms, interpersonal functioning, idiosyncratic complaints, and the presence of the diagnosis of depression. Additional measures include biological measures, narrative material (sessions, interviews), and health care costs.
This trial presents the test of an often-described, yet hardly investigated interaction between important personality dimensions and therapeutic approach in the treatment of depression. Results could inform therapists on how to match psychotherapeutic treatments to specific personality characteristics of their patients.
Isrctn.com, ISRCTN17130982 . Registered on 2 February 2015.
重度抑郁症是全球疾病负担的主要原因之一，这表明有效治疗方法的重要性。结果研究表明，不同类型的心理治疗在总体上对各群体有效，但群体内部存在很大差异。尽管患者特征在理解治疗结果方面被认为至关重要，但它们受到的研究关注有限。本试验旨在研究治疗方法（结构化与探索性）与患者人格类型（依赖型与自我批评型）之间的相互作用，人格类型被认为是抑郁病理的一个核心潜在维度。
方法/设计：本研究是一项在比利时弗拉芒进行的务实分层（依赖型和自我批评型患者）平行试验，采用均等随机化（分配比例为1:1）。将招募104名患者，并随机分为接受16 - 20节抑郁症认知行为疗法（结构化方法）或16 - 20节抑郁症短期心理动力心理疗法（探索性方法），由私人执业的经过培训的心理治疗师实施。主要结局是治疗结束时通过汉密尔顿抑郁量表测量的抑郁严重程度。次要结局指标包括自我报告的抑郁及其他症状、人际功能、特殊主诉以及抑郁症诊断的存在情况。其他测量指标包括生物学指标、叙事材料（治疗过程、访谈）和医疗保健成本。
本试验对抑郁症治疗中重要人格维度与治疗方法之间经常被描述但很少被研究的相互作用进行了检验。研究结果可为治疗师提供如何根据患者的特定人格特征匹配心理治疗方法的信息。
Isrctn.com，ISRCTN17130982。于2015年2月2日注册。
