Department of Psychology,Vanderbilt University,306 Wilson Hall,Nashville,TN 37240,USA.
Epidemiol Psychiatr Sci. 2016 Aug;25(4):295-300. doi: 10.1017/S2045796015000748. Epub 2015 Aug 27.
Depression is an eminently treatable disorder, although estimates of treatment efficacy have been inflated by publication bias. Patients with less severe depressions respond to even nonspecific interventions, whereas patients with more severe depressions require treatments that mobilize specific mechanisms. The cognitive and behavior therapies can be as efficacious as medications in the treatment of severe depression and have an enduring effect that medications lack. Medications may interfere with those enduring effects when added in combination and may prolong the life of the underlying episode when used alone. Thus the cognitive behavioral interventions might be the optimal first-line treatments for depression.
抑郁症是一种可以很好治疗的疾病，尽管疗效评估受到发表偏倚的影响。抑郁症状较轻的患者对非特异性干预也有反应，而抑郁症状较重的患者需要采用能调动特定机制的治疗方法。认知和行为疗法在治疗重度抑郁症方面与药物一样有效，且具有药物所缺乏的持久效果。当联合使用时，药物可能会干扰这些持久的效果，而单独使用时，药物可能会延长潜在发作的时间。因此，认知行为干预可能是治疗抑郁症的最佳一线治疗方法。
