Wang Po, DU Rui, Lin Lin, Ding Lin, Peng Kui, Xu Yu, Xu Min, Bi Yu Fang, Wang Wei Qing, Ning Guang, Lu Jie Li
National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
Biomed Environ Sci. 2017 Feb;30(2):128-133. doi: 10.3967/bes2017.016.
This current cross-sectional study investigates the relationship between thyroid hormones and peripheral artery disease (PAD) among euthyroid Chinese population aged 40 years and above. Serum free triiodothyronine (FT3), free thyroxin (FT4), thyroid-stimulating hormone (TSH), and thyroid antibodies were measured. PAD was defined as ankle-brachial index (ABI) < 0.9. There were 91 (2.9%) PAD cases among the 3,148 euthyroid study participants. Participants in the highest quartile of FT3 and free-triiodothyronine-to-free-thyroxin (FT3/FT4 ratio) had a decreased risk of prevalent PAD (multivariate-adjusted odds ratio, 95% confidence interval: 0.32, 0.15-0.62, P for trend = 0.01 and 0.31, 0.13-0.66, P for trend = 0.004, respectively) compared to those in the lowest quartile. To conclude, FT3 levels and the FT3/FT4 ratio was inversely associated with prevalent PAD in euthyroid Chinese population aged 40 years and above.
这项横断面研究调查了40岁及以上甲状腺功能正常的中国人群中甲状腺激素与外周动脉疾病（PAD）之间的关系。测量了血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和甲状腺抗体。PAD定义为踝臂指数（ABI）<0.9。在3148名甲状腺功能正常的研究参与者中，有91例（2.9%）PAD病例。与最低四分位数的参与者相比，FT3和游离三碘甲状腺原氨酸与游离甲状腺素比值（FT3/FT4比值）最高四分位数的参与者患现患PAD的风险降低（多变量调整比值比，95%置信区间：分别为0.32，0.15 - 0.62，趋势P = 0.01；以及0.31，0.13 - 0.66，趋势P = 0.004）。总之，在40岁及以上甲状腺功能正常的中国人群中，FT3水平和FT3/FT4比值与现患PAD呈负相关。
