Wnt/PCP信号通路对左右不对称性中纤毛的调控指令
Wnt/PCP Instructions for Cilia in Left-Right Asymmetry.
作者信息
Wu Jun, Mlodzik Marek
机构信息
Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA.
Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA.
出版信息
Dev Cell. 2017 Mar 13;40(5):423-424. doi: 10.1016/j.devcel.2017.02.023.
Abstract
Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientation within the epithelial plane, but whether Wnts are instructive or permissive is debated. Reporting in Developmental Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left-right asymmetry establishment.
摘要
Wnt-Frizzled/平面细胞极性（PCP）信号通路确立上皮平面内的细胞方向，但Wnts是起指导性作用还是允许性作用仍存在争议。峰岸等人（2017年）在《发育细胞》杂志上发表报告，揭示了从Wnt5a/b梯度到PCP因子调节的极化纤毛定位之间的指导性联系，这对于小鼠胚胎左右不对称的建立至关重要。
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本文引用的文献
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A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.Wnt5活性不对称性及通过平面细胞极性（PCP）蛋白的细胞间信号传导使节点细胞极化以打破左右对称性。
Dev Cell. 2017 Mar 13;40(5):439-452.e4. doi: 10.1016/j.devcel.2017.02.010.
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Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity.上皮细胞中的中心粒定位及其与平面细胞极性的密切关系。
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