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Wnt/PCP信号通路对左右不对称性中纤毛的调控指令

Wnt/PCP Instructions for Cilia in Left-Right Asymmetry.

作者信息

Wu Jun, Mlodzik Marek

机构信息

Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA.

Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA.

出版信息

Dev Cell. 2017 Mar 13;40(5):423-424. doi: 10.1016/j.devcel.2017.02.023.

DOI:10.1016/j.devcel.2017.02.023
PMID:28292419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5490791/
Abstract

Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientation within the epithelial plane, but whether Wnts are instructive or permissive is debated. Reporting in Developmental Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left-right asymmetry establishment.

摘要

Wnt-Frizzled/平面细胞极性（PCP）信号通路确立上皮平面内的细胞方向，但Wnts是起指导性作用还是允许性作用仍存在争议。峰岸等人（2017年）在《发育细胞》杂志上发表报告，揭示了从Wnt5a/b梯度到PCP因子调节的极化纤毛定位之间的指导性联系，这对于小鼠胚胎左右不对称的建立至关重要。

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本文引用的文献

1
A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.Wnt5活性不对称性及通过平面细胞极性（PCP）蛋白的细胞间信号传导使节点细胞极化以打破左右对称性。
Dev Cell. 2017 Mar 13;40(5):439-452.e4. doi: 10.1016/j.devcel.2017.02.010.
2
Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity.上皮细胞中的中心粒定位及其与平面细胞极性的密切关系。
Bioessays. 2016 Dec;38(12):1234-1245. doi: 10.1002/bies.201600154. Epub 2016 Oct 24.
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Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling.中心粒的定位是卷曲蛋白平面细胞极性信号传导的保守指标。
Nat Commun. 2016 Mar 29;7:11135. doi: 10.1038/ncomms11135.
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Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).Wnt-Frizzled/平面细胞极性信号传导：迎着风（Wnt）确定细胞方向。
Annu Rev Cell Dev Biol. 2015;31:623-46. doi: 10.1146/annurev-cellbio-100814-125315.
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Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila.Wg 和 Wnt4 为果蝇的平面细胞极性取向提供远程定向输入。
Nat Cell Biol. 2013 Sep;15(9):1045-55. doi: 10.1038/ncb2806. Epub 2013 Aug 4.
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Planar cell polarity signaling: coordination of cellular orientation across tissues.平面细胞极性信号传导：跨组织的细胞定向协调
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Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia.Vangl2 指导运动性初级纤毛的向后倾斜和不对称定位。
Nat Cell Biol. 2010 Apr;12(4):407-12. doi: 10.1038/ncb2042. Epub 2010 Mar 21.
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WNT11 acts as a directional cue to organize the elongation of early muscle fibres.WNT11作为一种定向信号来组织早期肌纤维的伸长。
Nature. 2009 Jan 29;457(7229):589-93. doi: 10.1038/nature07564. Epub 2008 Nov 5.
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Planar cell polarity: one or two pathways?平面细胞极性：一条还是两条信号通路？
Nat Rev Genet. 2007 Jul;8(7):555-63. doi: 10.1038/nrg2125. Epub 2007 Jun 12.
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De novo formation of left-right asymmetry by posterior tilt of nodal cilia.通过节点纤毛的向后倾斜从头形成左右不对称性。
PLoS Biol. 2005 Aug;3(8):e268. doi: 10.1371/journal.pbio.0030268. Epub 2005 Jul 26.