Han Jun, Zhou Lei, Ge Xinna, Guo Xin, Yang Hanchun
Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, PR China.
Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, PR China.
Vet Microbiol. 2017 Sep;209:30-47. doi: 10.1016/j.vetmic.2017.02.020. Epub 2017 Mar 2.
Porcine reproductive and respiratory syndrome virus (PRRSV) has remained a major threat to the worldwide swine industry ever since its first discovery in the early 1990s. Under the selective pressures in the field, this positive-stranded RNA virus undergoes rapid genetic evolution that eventually leads to emergence in 2006 of the devastating Chinese highly pathogenic PRRSV (HP-PRRSV). The atypical nature of HP-PRRSV has caused colossal economic losses to the swine producers in China and the surrounding countries. In this review, we summarize the recent advances in our understanding of the pathogenesis, evolution and ongoing field practices on the control of this troubling virus in China.
自20世纪90年代初首次发现以来，猪繁殖与呼吸综合征病毒（PRRSV）一直是全球养猪业的主要威胁。在田间的选择压力下，这种正链RNA病毒经历快速的基因进化，最终导致2006年具有毁灭性的中国高致病性PRRSV（HP-PRRSV）出现。HP-PRRSV的非典型性质给中国及周边国家的养猪生产者造成了巨大的经济损失。在这篇综述中，我们总结了近期在理解该病毒在中国的发病机制、进化以及当前防控措施方面取得的进展。
