莫舍尔方法在生物活性植物和真菌代谢产物绝对构型确定中的应用。

Application of Mosher's method for absolute configuration assignment to bioactive plants and fungi metabolites.

作者信息

Cimmino Alessio, Masi Marco, Evidente Marco, Superchi Stefano, Evidente Antonio

机构信息

Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cintia 4, 80126, Napoli, Italy.

Dipartimento di Scienze, Università degli Studi della Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.

出版信息

J Pharm Biomed Anal. 2017 Sep 10;144:59-89. doi: 10.1016/j.jpba.2017.02.037. Epub 2017 Feb 21.

DOI:10.1016/j.jpba.2017.02.037

PMID:28292560

Abstract

The review deals with the application of the NMR advanced Mosher's method for the assignment of the absolute configuration to plant and fungal metabolites belonging to different classes of natural compounds. The structural and stereochemical characterization of these naturally occurring metabolites, as well as their biological properties as possible drugs or agrochemicals is reviewed. The importance of the absolute and relative stereochemistry on their biological properties is also highlighted. Successes and failures of application of the advanced Mosher's method are reported.

摘要

本综述涉及核磁共振高级莫舍尔方法在确定不同类天然化合物的植物和真菌代谢产物绝对构型中的应用。综述了这些天然存在的代谢产物的结构和立体化学特征，以及它们作为潜在药物或农用化学品的生物学特性。还强调了绝对和相对立体化学对其生物学特性的重要性。报告了高级莫舍尔方法应用的成功与失败情况。