Yohannes Abebaw M, Chen W, Moga Ana M, Leroi I, Connolly Martin J
Manchester Metropolitan University, Manchester, United Kingdom.
University of British Columbia, Vancouver, Canada.
J Am Med Dir Assoc. 2017 May 1;18(5):451.e1-451.e11. doi: 10.1016/j.jamda.2017.01.014. Epub 2017 Mar 11.
Cognitive impairment is common in people living with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF); however, accurate estimates of prevalence are lacking. To date, there are no meta-analyses that have specifically investigated prevalence of mild cognitive impairment (MCI) in this particular population. Our aim was to undertake a systematic review and apply meta-analytic methods to estimate the prevalence of MCI and any cognitive impairment (ACI) in people with COPD and CHF.
We identified relevant studies for COPD and CHF by searching the published literature from inception to February 2016 using the MEDLINE and Web of Science databases. Studies were included if they documented the prevalence of MCI and/or cognitive impairment for COPD and CHF patients without dementia.
Seventeen studies including people with CHF (n = 29,456) and 14 studies including people with COPD (n = 23,116) were included. The pooled mean age for COPD was 66.3 years and for CHF, 75.6 years. The pooled prevalence of MCI in the COPD was 25% (95% CI: 23%, 42%) and ACI, 32% (95% CI: 18%, 38%). Correspondingly, the pooled prevalence of MCI in those with CHF was 32% (95% CI: 22%, 43%) and ACI, 31% (95% CI: 23%, 40%).
One in 4 people with COPD and 1 in 3 people with CHF had MCI, respectively. The overall prevalence of ACI for COPD was 32% and for CHF, 31%. Future work should consider ways of detecting, managing, or improving cognitive function and other cognition-related outcomes in this group of people.
认知障碍在慢性阻塞性肺疾病(COPD)和慢性心力衰竭(CHF)患者中很常见;然而,目前缺乏对其患病率的准确估计。迄今为止,尚无荟萃分析专门研究这一特定人群中轻度认知障碍(MCI)的患病率。我们的目的是进行一项系统评价,并应用荟萃分析方法来估计COPD和CHF患者中MCI和任何认知障碍(ACI)的患病率。
我们通过检索MEDLINE和科学引文索引数据库,从创刊至2016年2月的已发表文献中确定了有关COPD和CHF的相关研究。如果研究记录了无痴呆的COPD和CHF患者中MCI和/或认知障碍的患病率,则纳入研究。
纳入了17项包含CHF患者(n = 29456)的研究和14项包含COPD患者(n = 23116)的研究。COPD患者的合并平均年龄为66.3岁,CHF患者为75.6岁。COPD患者中MCI的合并患病率为25%(95%CI:23%,42%),ACI为32%(95%CI:18%,38%)。相应地,CHF患者中MCI的合并患病率为32%(95%CI:22%,43%),ACI为31%(95%CI:23%,40%)。
COPD患者中四分之一以及CHF患者中三分之一患有MCI。COPD患者中ACI的总体患病率为32%,CHF患者为31%。未来的工作应考虑检测、管理或改善该人群认知功能及其他与认知相关结局的方法。