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Pharmacologic Ascorbate in Myeloma Treatment: Doses Matter.

作者信息

Violet Pierre-Christian, Levine Mark

机构信息

Molecular and Clinical Nutrition Section, NIDDK, NIH, Bethesda, MD 20892, United States.

Molecular and Clinical Nutrition Section, NIDDK, NIH, Bethesda, MD 20892, United States.

出版信息

EBioMedicine. 2017 Apr;18:9-10. doi: 10.1016/j.ebiom.2017.03.014. Epub 2017 Mar 9.

DOI:10.1016/j.ebiom.2017.03.014
PMID:28292579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5405158/
Abstract
摘要

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Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials.癌症临床试验中静脉注射维生素C的系统评价。
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本文引用的文献

1
Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid.药物剂量的抗坏血酸能选择性杀死多发性骨髓瘤肿瘤细胞。
EBioMedicine. 2017 Apr;18:41-49. doi: 10.1016/j.ebiom.2017.02.011. Epub 2017 Feb 16.
2
Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial.硼替佐米联合来那度胺和地塞米松与单纯来那度胺和地塞米松治疗新诊断的无立即自体干细胞移植意向的骨髓瘤患者（SWOG S0777）：一项随机、开放标签的3期试验
Lancet. 2017 Feb 4;389(10068):519-527. doi: 10.1016/S0140-6736(16)31594-X. Epub 2016 Dec 23.
3
Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.静脉内给予抗坏血酸作为癌症治疗药物：基于药代动力学的再评估。
Antioxid Redox Signal. 2013 Dec 10;19(17):2141-56. doi: 10.1089/ars.2013.5372. Epub 2013 Jun 19.
4
Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.硼替佐米联合维生素 C 或绿茶提取物（表没食子儿茶素没食子酸酯）的抗肿瘤活性的临床前评价。
Cancer Chemother Pharmacol. 2011 Nov;68(5):1145-54. doi: 10.1007/s00280-011-1591-2. Epub 2011 Mar 13.
5
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.维生素 C：补充和替代医学从业者的静脉内使用及不良反应。
PLoS One. 2010 Jul 7;5(7):e11414. doi: 10.1371/journal.pone.0011414.
6
The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review.三氧化二砷治疗复发难治性多发性骨髓瘤的疗效：一项系统评价
Cancer Treat Rev. 2009 Aug;35(5):425-30. doi: 10.1016/j.ctrv.2009.04.007. Epub 2009 May 22.
7
Ascorbic acid inhibits antitumor activity of bortezomib in vivo.抗坏血酸在体内抑制硼替佐米的抗肿瘤活性。
Leukemia. 2009 Sep;23(9):1679-86. doi: 10.1038/leu.2009.83. Epub 2009 Apr 16.
8
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.药理学剂量的抗坏血酸盐可作为一种促氧化剂，并减少小鼠体内侵袭性肿瘤异种移植物的生长。
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4.
9
Vitamin C pharmacokinetics: implications for oral and intravenous use.维生素C的药代动力学：对口服和静脉使用的意义。
Ann Intern Med. 2004 Apr 6;140(7):533-7. doi: 10.7326/0003-4819-140-7-200404060-00010.