Zinovkin Roman A, Lyamzaev Konstantin G, Chernyak Boris V
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
The "Russian Clinical Research Center for Gerontology" of the Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, Moscow, Russia.
Front Cell Dev Biol. 2023 Mar 16;11:1048177. doi: 10.3389/fcell.2023.1048177. eCollection 2023.
Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement becomes more complex. On the one hand, ROS are necessary for cancer progression and epithelial-mesenchymal transition. On the other hand, antioxidants may promote cancer cell survival and may increase metastatic frequency. The role of mitochondrial ROS in cancer development remains largely unknown. This paper reviews experimental data on the effects of both endogenous and exogenous antioxidants on cancerogenesis focusing on the development and application of mitochondria-targeted antioxidants. We also discuss the prospects for antioxidant cancer therapy, focusing on the use of mitochondria-targeted antioxidants.
氧化应激几乎始终伴随着癌症发展的各个阶段。在早期阶段，抗氧化剂可能有助于减少活性氧（ROS）的产生并发挥抗癌作用。在后期阶段，ROS的参与变得更加复杂。一方面，ROS对于癌症进展和上皮-间质转化是必需的。另一方面，抗氧化剂可能促进癌细胞存活并可能增加转移频率。线粒体ROS在癌症发展中的作用在很大程度上仍然未知。本文综述了关于内源性和外源性抗氧化剂对癌症发生影响的实验数据，重点关注线粒体靶向抗氧化剂的开发和应用。我们还讨论了抗氧化剂癌症治疗的前景，重点是线粒体靶向抗氧化剂的使用。
