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供者年龄对儿童患者去T细胞单倍体相合造血干细胞移植至关重要：使用年轻供者可实现更快的免疫重建。

Donor age matters in T-cell depleted haploidentical hematopoietic stem cell transplantation in pediatric patients: Faster immune reconstitution using younger donors.

作者信息

González-Vicent Marta, Molina Blanca, Deltoro Natalia, Sevilla Julián, Vicario José Luis, Castillo Ana, Ramirez Manuel, Díaz Miguel Ángel

机构信息

Stem Cell Transplant Unit, Hospital Niño Jesus, Madrid, Spain.

Stem Cell Transplant Unit, Hospital Niño Jesus, Madrid, Spain.

出版信息

Leuk Res. 2017 Jun;57:60-64. doi: 10.1016/j.leukres.2017.03.001. Epub 2017 Mar 4.

DOI:10.1016/j.leukres.2017.03.001
PMID:28292719
Abstract

T-cell depleted (TCD) haploidentical transplantation is increasingly used in paediatric patients with haematological malignancies and donor selection is a challenge. We conclude that a simple criterion such as donor age should be also considered in depleted haploidentical setting because faster immune reconstitution is achieved using younger donors decreasing non-relapse related mortality.

摘要

T细胞去除（TCD）的单倍体相合移植越来越多地用于患有血液系统恶性肿瘤的儿科患者，而供体选择是一项挑战。我们得出结论，在去除T细胞的单倍体相合移植情况下，也应考虑诸如供体年龄这样的简单标准，因为使用较年轻的供体可实现更快的免疫重建，从而降低非复发相关死亡率。

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