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衰老宿主中的免疫重建：同种异体造血细胞移植中基于机制的治疗机会。

Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation.

机构信息

Adult Bone Marrow Transplantation (BMT) Service, Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Department of Medicine, Weill Cornell Medical College, New York, NY, United States.

出版信息

Front Immunol. 2021 Apr 19;12:674093. doi: 10.3389/fimmu.2021.674093. eCollection 2021.

DOI:10.3389/fimmu.2021.674093
PMID:33953731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8089387/
Abstract

Older patients with hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplantation with encouraging outcomes. While aging-related thymic dysfunction remains a major obstacle to optimal and timely immune reconstitution post- transplantation, recent accumulating evidence has suggested that various aging hallmarks such as cellular senescence, inflamm-aging, and hematopoietic stem cell exhaustion, could also impact immune reconstitution post-transplantation in both thymic-dependent and independent manner. Here we review molecular and cellular aspects of immune senescence and immune rejuvenation related to allogeneic hematopoietic cell transplantation among older patients and discuss potential strategies for mechanism-based therapeutic intervention.

摘要

越来越多患有血液系统恶性肿瘤的老年患者被考虑接受异基因造血细胞移植，其结果令人鼓舞。尽管与年龄相关的胸腺功能障碍仍然是移植后获得最佳和及时免疫重建的主要障碍，但最近越来越多的证据表明，各种衰老特征，如细胞衰老、炎症衰老和造血干细胞衰竭，也可能以依赖和不依赖于胸腺的方式影响移植后的免疫重建。在这里，我们回顾了与老年患者异基因造血细胞移植相关的免疫衰老和免疫更新的分子和细胞方面，并讨论了基于机制的治疗干预的潜在策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/8089387/6c4c50a8581c/fimmu-12-674093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/8089387/6c4c50a8581c/fimmu-12-674093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/8089387/6c4c50a8581c/fimmu-12-674093-g001.jpg

相似文献

[1]
Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation.

Front Immunol. 2021

[2]
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[3]
Use of Multivariate Immune Reconstitution Patterns to Describe Immune Reconstitution after Allogeneic Stem Cell Transplantation in Children.

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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells May Lead to Impaired Antibody Immune Reconstitution.

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引用本文的文献

[1]
Aging-related, senescence-associated secretory phenotype and allogeneic hematopoietic cell transplantation outcomes in older patients.

J Geriatr Oncol. 2025-8-19

[2]
Allogeneic Transplantation for Older Adults.

Adv Exp Med Biol. 2025

[3]
Prevalence of VZV Reactivation and Effectiveness of Vaccination with Recombinant Adjuvanted Zoster Vaccine in Allogeneic Hematopoietic Stem Cell Recipients-A Single-Center Analysis.

Infect Dis Rep. 2025-5-2

[4]
Comparison of oral zinc supplement and placebo effect in improving the T-cells regeneration in patients undergoing autologous hematopoietic stem cell transplantation: Clinical trial study.

Medicine (Baltimore). 2024-12-20

[5]
Stem cell decoupling underlies impaired lymphoid development during aging.

Proc Natl Acad Sci U S A. 2023-5-30

[6]
Allogeneic hematopoietic cell transplantation for older patients.

Hematology Am Soc Hematol Educ Program. 2021-12-10

[7]
Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System.

Int J Mol Sci. 2021-5-27

本文引用的文献

[1]
Viral Infections in HSCT: Detection, Monitoring, Clinical Management, and Immunologic Implications.

Front Immunol. 2021-1-20

[2]
Senescence and the SASP: many therapeutic avenues.

Genes Dev. 2020-12-1

[3]
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche.

J Exp Med. 2021-3-1

[4]
Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.

J Hematol Oncol. 2020-11-23

[5]
T cell regeneration after immunological injury.

Nat Rev Immunol. 2021-5

[6]
Evaluating Thymic Function After Human Hematopoietic Stem Cell Transplantation in the Personalized Medicine Era.

Front Immunol. 2020

[7]
Mitochondria, immunosenescence and inflammaging: a role for mitokines?

Semin Immunopathol. 2020-10

[8]
The function of the thymus and its impact on modern medicine.

Science. 2020-7-31

[9]
Hematopoietic Stem Cell Metabolism during Development and Aging.

Dev Cell. 2020-7-20

[10]
Senolytic CAR T cells reverse senescence-associated pathologies.

Nature. 2020-6-17

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