Bostan Hasan Badie, Mehri Soghra, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Neurocognitive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2017 Feb;20(2):110-121. doi: 10.22038/ijbms.2017.8230.
Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron. However, a comprehensive review that covers all aspects of its toxicity has not been published yet. The current study provides classified information about the toxic effects of saffron and its constituents in various exposure conditions including acute, sub-acute, sub-chronic and chronic studies. Therapeutic doses of saffron exhibits no significant toxicity in both clinical and experimental investigations.
藏红花（番红花）自古以来就被视为药用植物，还因其颜色、味道和气味而被广泛用作食品添加剂。人们已使用不同的体内和体外模型对藏红花及其主要成分藏红花素和藏红花醛的药理特性进行了评估。此外，其他研究发现了藏红花的毒理学效应。然而，尚未发表涵盖其毒性所有方面的全面综述。本研究提供了关于藏红花及其成分在各种暴露条件（包括急性、亚急性、亚慢性和慢性研究）下的毒性作用的分类信息。在临床和实验研究中，治疗剂量的藏红花均未表现出明显毒性。
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