藏红花在缺血性中风中的治疗潜力
Therapeutic Potential of Saffron ( L.) in Ischemia Stroke.
作者信息
Azami Shakiba, Shahriari Zahra, Asgharzade Samira, Farkhondeh Tahereh, Sadeghi Mahmood, Ahmadi Fatemeh, Vahedi Mohammad Mahdi, Forouzanfar Fatemeh
机构信息
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Evid Based Complement Alternat Med. 2021 Mar 2;2021:6643950. doi: 10.1155/2021/6643950. eCollection 2021.
Abstract
Stroke is the second leading cause of death and a main cause of disability worldwide. The majority (approximately 80%) of strokes are ischemic. Saffron ( L.) has been considered for medicinal purposes since ancient times. Pharmacological effects of saffron are attributed to the presence of crocin, crocetin, picrocrocin, and safranal. In the present review, we summarized the reported neuroprotective effects of saffron and its active constituents against cerebral ischemia stroke. Saffron and its components exert its beneficial effects as an antioxidant, anti-inflammatory, and antiapoptotic agent though inhibition of biochemical, inflammatory, and oxidative stress markers. Taken together, this review indicates that saffron and its ingredients could be a potent candidate in the process of new drug production for the treatment of ischemia stroke.
摘要
中风是全球第二大致死原因和主要致残原因。大多数（约80%）中风为缺血性中风。藏红花自古以来就被用于药用。藏红花的药理作用归因于西红花苷、西红花酸、苦藏花素和藏花醛的存在。在本综述中，我们总结了藏红花及其活性成分对脑缺血性中风的神经保护作用报道。藏红花及其成分通过抑制生化、炎症和氧化应激标志物，作为抗氧化剂、抗炎剂和抗凋亡剂发挥有益作用。综上所述，本综述表明藏红花及其成分可能是缺血性中风治疗新药研发过程中的有力候选药物。
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