藏红花减轻了其成分藏红花醛在大鼠急性和亚急性毒性中的毒性作用。
Saffron reduced toxic effects of its constituent, safranal, in acute and subacute toxicities in rats.
作者信息
Ziaee Toktam, Razavi Bibi Marjan, Hosseinzadeh Hossein
机构信息
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran.
出版信息
Jundishapur J Nat Pharm Prod. 2014 Feb;9(1):3-8. doi: 10.17795/jjnpp-13168. Epub 2014 Feb 20.
BACKGROUND
Saffron and its constituents are widely used around the world as a spice and medicinal plant. Different constituents in medicinal herbs are thought to have the potential to induce useful and/or adverse effects. So, efforts have been made to find the best and most valuable tools to reduce their adverse effects.
OBJECTIVES
According to Iranian traditional medicine (ITM), it is believed that administration of whole herbs exhibits more activity and fewer side effects than isolated constituents. Since toxicological studies have indicated that safranal is more toxic than other active components in saffron stigma, thus this study was undertaken to evaluate the effect of co-administration of saffron extract and safranal in acute and sub-acute toxicities in rats.
MATERIALS AND METHODS
In acute toxicity, rats received safranal (1.2 mL/kg, IP) plus saffron aqueous extract (25-100 mg/kg, IP). One and four days after the treatment, percentage of mortality was assessed. In subacute toxicity, rats were randomly divided into six groups. Group 1) safranal (0.2 mL/kg, IP), Groups 2, 3 and 4) safranal plus saffron aqueous extract (5, 10 and 20 mg/kg, IP) Groups 5 and 6) Paraffin and normal saline, as solvents of safranal and saffron aqueous extract, respectively. Treatments were continued for 21 days. For sub-acute toxicity, the percentages of lethality as well as some biochemical parameters were evaluated.
RESULTS
Our results showed that four days co-treatment of safranal and saffron significantly reduced mortality, so that the effect was more obvious in lower doses. Sub-acute toxicity studies showed that saffron could increase survival in rats so that no mortality was observed at dose of 10 mg/kg. Our data also indicated that the levels of triglyceride, BUN and ALT significantly increased after sub-acute interaperitoneal (IP) administration of safranal (0.2 mL/kg/day) and co-treatment of saffron aqueous extract (5 and 10 mg/kg) plus safranal significantly improved all toxic effects of safranal on biochemical parameters.
CONCLUSIONS
The co-administration of saffron aqueous extract and safranal reduced toxic effects of safranal in acute and sub-acute toxicities.
背景
藏红花及其成分在世界各地被广泛用作香料和药用植物。人们认为药草中的不同成分有可能产生有益和/或有害的影响。因此，人们一直在努力寻找最佳和最有价值的方法来减少其不良影响。
目的
根据伊朗传统医学（ITM），人们认为服用全草比服用分离成分具有更多的活性和更少的副作用。由于毒理学研究表明，藏红花醛比藏红花柱头中的其他活性成分毒性更大，因此本研究旨在评估藏红花提取物和藏红花醛联合给药对大鼠急性和亚急性毒性的影响。
材料与方法
在急性毒性实验中，大鼠接受藏红花醛（1.2 mL/kg，腹腔注射）加藏红花水提取物（25 - 100 mg/kg，腹腔注射）。治疗后1天和4天，评估死亡率。在亚急性毒性实验中，大鼠被随机分为六组。第1组）藏红花醛（0.2 mL/kg，腹腔注射），第2、3和4组）藏红花醛加藏红花水提取物（5、10和20 mg/kg，腹腔注射），第5和6组）分别为作为藏红花醛和藏红花水提取物溶剂的石蜡和生理盐水。治疗持续21天。对于亚急性毒性，评估致死率百分比以及一些生化参数。
结果
我们的结果表明，藏红花醛和藏红花联合治疗4天显著降低了死亡率，在较低剂量下效果更明显。亚急性毒性研究表明，藏红花可以提高大鼠的存活率，在10 mg/kg剂量下未观察到死亡。我们的数据还表明，亚急性腹腔注射藏红花醛（0.2 mL/kg/天）后，甘油三酯、尿素氮和谷丙转氨酶水平显著升高，藏红花水提取物（5和10 mg/kg）与藏红花醛联合治疗显著改善了藏红花醛对生化参数的所有毒性作用。
结论
藏红花水提取物和藏红花醛联合给药降低了藏红花醛在急性和亚急性毒性中的毒性作用。
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