Hashaad Nashwa Ismail, Fawzy Rasha Mohamed, Elazem Abeer Ahmed Abo, Youssef Mohamed Ibrahim
Department of Rheumatology, Rehabilitation and Physical Medicine, Benha University School of Medicine, Benha, Egypt.
Department of Microbiology and Immunology, Benha University School of Medicine, Benha, Egypt.
Eur J Rheumatol. 2017 Mar;4(1):19-23. doi: 10.5152/eurjrheum.2017.160071. Epub 2017 Mar 1.
This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity parameters in juvenile idiopathic arthritis (JIA).
In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity was done via gray-scale ultrasonography (US) and power Doppler US (PDUS). Enzyme-linked immunosorbent assay (ELISA) was used to assay the serum level of human CRT.
The mean serum CRT levels in JIA patients was 8.6±1.2 ng/mL and showed a highly significant increase (p=0.001) as compared to the mean serum levels in the controls (5.02±0.77 ng/mL). There were statistically significant positive correlations between the serum CRT levels and disease duration, tender joint count, swollen joint count, visual analog scale, erythrocyte sedimentation rate, JADAS-27, C-reactive protein, rheumatoid factor titer, and ultrasonographic grading for synovitis and neovascularization.
Elevated serum CRT levels in JIA patients and its correlations with JIA disease activity and severity parameters signified that CRT might be used as a novel biomarker for disease activity and severity in JIA.
本研究旨在探讨青少年特发性关节炎（JIA）患者血清钙网蛋白（CRT）水平与疾病活动度及严重程度参数之间的关系。
本研究纳入了60例JIA患儿和50例年龄及性别匹配的健康受试者。采用青少年关节炎疾病活动度评分27（JADAS-27）评估疾病活动度。通过灰阶超声（US）和能量多普勒超声（PDUS）评估疾病严重程度。采用酶联免疫吸附测定（ELISA）法检测人CRT的血清水平。
JIA患者的血清CRT平均水平为8.6±1.2 ng/mL，与对照组的平均血清水平（5.02±0.77 ng/mL）相比，呈现出高度显著的升高（p = 0.001）。血清CRT水平与疾病持续时间、压痛关节数、肿胀关节数、视觉模拟评分、红细胞沉降率、JADAS-27、C反应蛋白、类风湿因子滴度以及滑膜炎和新生血管形成的超声分级之间存在统计学显著的正相关。
JIA患者血清CRT水平升高及其与JIA疾病活动度和严重程度参数的相关性表明，CRT可能作为JIA疾病活动度和严重程度的一种新型生物标志物。
