Fan Xing, Dong Ming, Li Tong, Ma Qiaoxin, Yin Yue
Maxillofacial Surgery of the Third Hospital Affiliated to Fourth Military Medical University, Xi'an, China; Department of Industrial Engineering, Xidian University, Xi'an, China; and Cosmetic Surgery of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Plast Reconstr Surg Glob Open. 2016 Dec 7;4(12):e1112. doi: 10.1097/GOX.0000000000001112. eCollection 2016 Dec.
Hyaluronic acid (HA) is one of the natural components of the human body with high biocompatibility, biodegradability, and nonimmunogenicity, which makes it the ideal biomedical filling agent currently available. However, for many medical practitioners, HA filler injections remain a relatively new item to carry out. Learning while practicing, it is inevitable to encounter some difficulties and adverse reactions in its application. Here we report two cases of adverse reactions to HA-based filler injections, including anaphylactic reaction on the face and vascular thrombosis after augmentation rhinoplasty with HA filler. In this report, we highlight the management and prevention of the adverse reactions, especially in case 2, because vascular thrombosis is one of the severe complications and injectors should know how to avoid it and how to deal with it, thereby increasing the safety of HA-based procedures.
透明质酸（HA）是人体的天然成分之一，具有高生物相容性、生物降解性和非免疫原性，这使其成为目前理想的生物医学填充剂。然而，对于许多医学从业者来说，HA填充剂注射仍是一项相对较新的操作项目。在实践中学习时，其应用过程中不可避免地会遇到一些困难和不良反应。在此，我们报告两例基于HA的填充剂注射不良反应病例，包括面部过敏反应和HA填充剂隆鼻术后血管血栓形成。在本报告中，我们重点介绍了不良反应的处理和预防，尤其是在病例2中，因为血管血栓形成是严重并发症之一，注射者应知道如何避免和处理，从而提高基于HA的手术的安全性。
