Department of Dermatology & Venerology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Skin Research Center, Landproof Testing Technology Co., Ltd, Guangzhou, Guangdong Province, China.
Photochem Photobiol. 2017 Oct;93(5):1276-1281. doi: 10.1111/php.12752. Epub 2017 May 9.
Although there have been some studies about changes of skin erythema and pigmentation following ultraviolet radiation in other races, the relevant data in Chinese have never been achieved. Thus, we evaluated the long-time course of skin erythema, pigmentation and hydration changes after different doses of solar-simulated ultraviolet (SSUV) irradiation in 26 Chinese women for 168 days. The erythema index increased abruptly and peaked during 3 days of SSUV exposure, then slowly returned to the baseline level starting at day 7 and completely recovered during 168-day course of this study only in one minimal erythema doses (MED) SSUV irradiation. The melanin index started to slowly increase at day 3 of SSUV exposure, peaking at day 14 and gradually returned to the baseline level thereafter, but did not return to the baseline level during 168-day course in all doses. Skin hydration slowly declined at day 3 of exposure, hitting the lowest point at day 7, then slowly recovered starting at day 14 and completely returned to the baseline level at day 28 only in 1.5MED. These results will serve as baseline data on Chinese skin and provide useful references for the treatment of serious skin photodamage in Chinese.
尽管已经有一些关于其他种族人群在紫外线照射后皮肤红斑和色素沉着变化的研究，但中国尚未有相关数据。因此，我们评估了 26 名中国女性在 168 天内接受不同剂量的模拟太阳紫外线（SSUV）照射后皮肤红斑、色素沉着和水分变化的长期过程。红斑指数在 SSUV 暴露的前 3 天急剧上升并达到峰值，然后从第 7 天开始缓慢恢复到基线水平，只有在一个最小红斑剂量（MED）SSUV 照射组中在整个研究期间完全恢复。黑素指数在 SSUV 暴露的第 3 天开始缓慢增加，在第 14 天达到峰值，此后逐渐恢复到基线水平，但在所有剂量组中，168 天内均未恢复到基线水平。皮肤水分在暴露的第 3 天开始缓慢下降，在第 7 天达到最低点，然后从第 14 天开始缓慢恢复，只有在 1.5MED 组中在第 28 天完全恢复到基线水平。这些结果将作为中国皮肤的基础数据，为中国严重皮肤光损伤的治疗提供有用的参考。
