Khiljee Tanzila, Akhtar Naveed, Khiljee Sonia, Khiljee Bushra, Rasheed Hafiz Majid, Ansari Siddique Akber, Alkahtani Hamad M, Ansari Irfan Aamer
Faculty of Pharmacy and Alternative Medicines, The Islamia University of Bahawalpur, Punjab 63100, Pakistan.
Shahida Islam College of Pharmacy, Shahida Islam Medical Complex, Lodhran 59320, Pakistan.
Gels. 2023 Nov 28;9(12):934. doi: 10.3390/gels9120934.
The aim of this study was to evaluate the moisturizing efficacy of quince fruit, used in folk medicine. For this purpose, the phytoconstituents of fruit extract, like phenolics and flavonoids, were determined. A stable cosmetic emulgel containing 4% fresh fruit extract was formulated and subjected to in vivo evaluation compared with a control.
fresh fruit extract was evaluated for tyrosinase activity and phenolic and flavonoid content. A stable emulgel containing 4% fresh fruit extract was formulated and tested in a skin irritation test. After this, in vivo tests of erythema, moisture, sebum, and skin elasticity were conducted. The in vivo evaluation was a randomized and single-blind study. Thirteen healthy female volunteers were selected for a three-month study period.
fruit extract showed good phenolic and flavonoid content, which was associated with its good antioxidant and tyrosinase-inhibiting activity. containing the emulgel showed a reduction in sebum and erythema, while the elasticity and moisture content showed increments in their levels after the three-month application of the formulation. The fruit contains chlorogenic acid and many sugars, which might account for its anti-inflammatory and sebum reduction effects; it is also capable of enhancing the skin's hydration level and decreasing skin sagging by enhancing its elasticity.
The emulgel loaded with fresh fruit extract is verified regarding its folklore status as a moisturizing agent that enhances the facial skin cells' resilience potential.
本研究的目的是评估民间医学中使用的榅桲果实的保湿功效。为此,测定了果实提取物的植物成分,如酚类和黄酮类化合物。制备了一种含有4%新鲜果实提取物的稳定化妆品乳化凝胶,并与对照组进行了体内评估。
对新鲜果实提取物的酪氨酸酶活性、酚类和黄酮类含量进行评估。制备了一种含有4%新鲜果实提取物的稳定乳化凝胶,并进行了皮肤刺激性试验。此后,进行了红斑、水分、皮脂和皮肤弹性的体内试验。体内评估是一项随机单盲研究。选择了13名健康女性志愿者进行为期三个月的研究。
果实提取物显示出良好的酚类和黄酮类含量,这与其良好的抗氧化和酪氨酸酶抑制活性相关。含有该乳化凝胶的制剂在三个月的应用后,皮脂和红斑减少,而弹性和水分含量增加。该果实含有绿原酸和多种糖类,这可能是其抗炎和减少皮脂作用的原因;它还能够通过增强皮肤弹性来提高皮肤的水合水平并减少皮肤松弛。
含有新鲜果实提取物的乳化凝胶作为一种增强面部皮肤细胞恢复潜力的保湿剂,其民间传说地位得到了验证。