Tanev Kaloyan S, Winokur Andrew, Pitman Roger K
From the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (KST, RKP); and the Department of Psychiatry, University of Connecticut Health Center, Farmington, Conn. (AW).
J Neuropsychiatry Clin Neurosci. 2017 Summer;29(3):248-253. doi: 10.1176/appi.neuropsych.16090166. Epub 2017 Mar 15.
The authors examined 28 dementia inpatients receiving treatment as usual. Beginning-to-end differences in neuropsychiatric symptoms and actigraphic sleep patterns were measured. Using a mixed-model, the authors regressed neuropsychiatric symptoms on average sleep minutes (between-subjects effect) and each night's deviation from average (within-subject effect). Sleep did not significantly differ from beginning to end of participation, whereas neuropsychiatric symptoms did. Average sleep minutes predicted average neuropsychiatric symptoms (p=0.002), but each night's deviation from the average did not predict next day's symptoms (p=0.90). These findings raise questions about the immediate benefits of treating sleep-wake disturbances on neuropsychiatric symptoms in hospitalized inpatients with dementias.
作者对28名接受常规治疗的痴呆症住院患者进行了检查。测量了神经精神症状和活动记录仪睡眠模式的从头到尾的差异。作者使用混合模型，将神经精神症状回归到平均睡眠时间（组间效应）和每晚与平均水平的偏差（组内效应）上。参与期间开始和结束时的睡眠没有显著差异，而神经精神症状有差异。平均睡眠时间可预测平均神经精神症状（p = 0.002），但每晚与平均水平的偏差不能预测次日症状（p = 0.90）。这些发现引发了关于治疗痴呆症住院患者睡眠-觉醒障碍对神经精神症状的即时益处的疑问。
